摘要
目的分析单唾液酸四己糖神经节苷脂联合普瑞巴林和甲钴胺治疗带状疱疹后神经痛(postherpetic neuralgia,PHN)的效果。方法选取2016年6月至2019年1月安徽医科大学附属巢湖医院收治的PHN患者98例为研究对象,采用随机数字表法将其分为对照组和观察组,每组各49例。对照组患者接受甲钴胺和普瑞巴林治疗,观察组患者在对照组治疗基础上加用单唾液酸四己糖神经节苷脂注射液治疗,两组患者疗程均为2周。比较两组患者治疗前后视觉模拟评分法(visual analogue scale,VAS)评分、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分、皮肤病生活质量指数(dermatology life quality index,DLQI)评分、治疗效果和不良反应发生情况。结果两组患者治疗前VAS、HAMD、PSQI和DLQI评分比较差异均无统计学意义(均P>0.05)。治疗后,两组患者上述评分较本组治疗前均显著降低(均P<0.05),其中观察组患者上述评分均显著低于对照组(均P<0.05)。观察组患者治疗总有效率显著高于对照组(P<0.05),两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论单唾液酸四己糖神经节苷脂联合普瑞巴林和甲钴胺治疗PHN,疗效显著,安全性高,无明显不良反应,值得临床应用。
Objective To study the effects of monosialotetrahexosylganglioside combined with pregabalin and mecobalamine in the treatment of postherpetic neuralgia(PHN).Method 98 patients with PHN admitted to Chaohu Hospital of Anhui Medical University from June 2016 to January 2019 were randomly divided into control group and observation group by random number table method,49 cases in each group.Control group patients were treated with mecobalamine and pregabalin.Observation group patients were treated with monosialotetrahexosylganglioside on the basis of control group.The course of treatment was last for 2 weeks.The scores of visual analogue scale(VAS),Hamilton depression scale(HAMD),Pittsburgh sleep quality index(PSQI),dermatology life quality index(DLQI)before and after treatment,curative effects and adverse reactions were compared between the two groups.Result There were no significant differences in VAS,HAMD,PSQI and DLQI scores between the two groups before treatment(all P>0.05).After treatment,the above-mentioned scores of the two groups of patients were significantly lower than those before treatment(all P<0.05),and the above-mentioned scores of observation group were significantly lower than those of control group(all P<0.05).The effective rate of observation group was significantly higher than that of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Monosialotetrahexosylganglioside combined with pregabalin and mecobalamine in the treatment of PHN has obvious curative effect,high safety and no obvious adverse reactions,which is worthy of clinical application.
作者
金学廷
Jin Xueting(Pain Department,Chaohu Hospital of Anhui Medical University,Anhui,Chaohu 238000,China)
出处
《中国医学前沿杂志（电子版）》
2020年第4期94-97,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
