摘要
目的 探讨奥洛他定滴眼液联合聚乙二醇滴眼液治疗过敏性结膜炎的临床效果.方法 选取2018年1月~2019年6月我院收治的过敏性结膜炎患者120例(120眼),按照随机数字表法分为试验组和对照组,每组各60例(60眼).对照组应用奥洛他定滴眼液治疗,试验组应用奥洛他定滴眼液联合聚乙二醇滴眼液治疗,比较两组患者的临床症状和体征变化、泪膜破裂时间(BUT)、泪液分泌试验(Schimer Ⅰ试验)结果、角膜荧光素染色情况、临床疗效及不良反应发生情况.结果 两组患者治疗前的临床症状和体征评分、BUT、Schimer Ⅰ试验及角膜荧光素染色评分比较,差异无统计学意义(P>0.05);两组患者治疗2周后的临床症状和体征评分及角膜荧光素染色评分均低于治疗前,BUT及SchimerⅠ试验结果均长于治疗前,差异有统计学意义(P<0.05);试验组患者治疗2周后的临床症状和体征评分及角膜荧光素染色评分均低于对照组,BUT及Schimer Ⅰ试验结果均长于对照组,差异有统计学意义(P<0.05);试验组患者的治疗总有效率为91.7%,高于对照组的78.3%,差异有统计学意义(P<0.05);所有患者治疗期间均未发生不良反应,原有疾病及眼部症状无加重.结论 奥洛他定联合聚乙二醇滴眼液治疗过敏性结膜炎的临床效果显著,且不良反应少,操作简便,是一种安全、有效的治疗方法,值得在临床中推广使用.
Objective To explore the clinical effect of Olopatadine combined with Polyethylene Glycol Eye Drops in the treatment of allergic conjunctivitis.Methods Atota of 120 patients(120 eyes)with allergic conjunctivitis who were treated in our hospital from January 2018 to June 2019 were selected,and divided into test group and control group by random number table method,with 60 cases(60 eyes)in each group.The control group was treated with Olopatadine Eye Drops.The test group was treated with Olopatadine and Polyethylene Glycol Eye Drops.The changes of clinical symptoms and signs,break up time(BUT),tear secretion test(SchimerⅠtest),corneal fluorescein staining,treatment effect and adverse reaction were compared between the two groups.Results There was no significant difference between the two groups in clinical symptoms and signs,BUT,schimerⅠtest and corneal fluorescein staining before treatment(P>0.05).The symptom and sign scores and corneal fluorescein staining scores of the two groups after 2 weeks of treatment were lower than those before treatment,BUT and SchimerⅠtest were longer than those before treatment,and the differences were statistically significant(P<0.05).The symptom and sign score and corneal fluorescein staining score of the test group were lower than those of the control group,BUT and SchimerⅠtest were longer than those of the control group,the differences were statistically significant(P<0.05).The total effective rate of the test group was 91.7%,which was higher than that of control group(78.3%),and the difference was statistically significant(P<0.05).All patients did not have adverse reactions during treatment,the original disease and ocular symptoms were not aggravated.Conclusion The clinical effect of Olopatadine combined with Polyethylene Glycol Eye Drops in the treatment of allergic conjunctivitis is significant,and with less adverse reactions,easy to operate.So it is a safe and effective treatment,which worth to promote the application in clinic.
作者
修鑫鑫
赵键
XIU Xin-xin;ZHAO Jian(Department of Ophthalmology,Fuxin General Hospital,Liaoning Health Industry Group,Fuxin123000,China)
出处
《中国当代医药》
2020年第8期127-130,共4页
China Modern Medicine
关键词
奥洛他定滴眼液
聚乙二醇滴眼液
过敏性结膜炎
治疗效果
Olopatadine Eye Grops
Polyethylene Glycol Eye Drops
Allergic conjunctivitis
Therapeutic effect
