摘要
目的:探讨临床药师在卡培他滨与替吉奥联用导致严重不良反应的临床判断及对症处理中所发挥的作用。方法:临床药师通过对卡培他滨与替吉奥联用导致严重不良反应的病例分析,探讨二者联用与严重不良反应的相关性,提出氟尿嘧啶过量导致严重毒性的应对措施。结果:临床药师积极参与患者救治过程,对不合理医嘱进行干预,及时协助医师调整患者给药方案,患者病情得以好转。结论:临床药师关注药物不良反应,协助医师保障临床用药安全。
Objective:To investigate the role of clinical pharmacists in the clinical judgment and symptomatic treatment of severe adverse reactions caused by the combination of capecitabine with tegafur,gimeracil and oteracil potassium capsules.Methods:The clinical pharmacist analyzed the case of severe adverse reactions caused by the combination of capecitabine with tegafur,gimeracil and oteracil potassium capsules,explored the correlation between the combined use of two drugs and the occurrence of serious adverse reactions and then proposed countermeasures for serious adverse reactions caused by excessive fluorouracil.Results:The clinical pharmacist actively participated in the patient treatment process,intervened with unreasonable doctor’s orders during the treatment process and assisted the doctor to adjust the patient's dosing schedule in time,which finally made the patient's conditions to be improved.Conclusion:Clinical pharmacists can assist physicians in ensuring the safety of clinical medication by focusing on adverse drug reactions.
作者
李娟
方英立
LI Juan;FANG Yingli(Department of Clinical Pharmacy,Qilu Hospital of Shandong University,Ji’nan 250012,China;Department of Clinical Pharmacy,the Second Hospital of Shandong University,Ji’nan 250033,China)
出处
《上海医药》
CAS
2020年第7期54-57,共4页
Shanghai Medical & Pharmaceutical Journal
关键词
卡培他滨
替吉奥
不良反应
药学监护
capecitabine
tegafur
gimeracil and oteracil potassium capsules
adverse reactions
pharmaceutical care
