摘要
目的:探讨美托洛尔联合参麦注射液对感染性休克患者心肌损伤的保护效应。方法:于2016年9月-2019年9月,选择笔者所在医院急诊科100例感染性休克患者,随机分为两组,每组50例。在基础治疗基础上,对照组给予美托洛尔,观察组给予美托洛尔联合参麦注射液,比较血流动力学、心肌酶、炎性因子、心律失常发生率。结果:与对照组相比,观察组治疗后的心率、心脏指数、心肌酶指标、炎性因子水平更低,其平均动脉压、每搏输出量指数更高(P<0.05)。两组各类心律失常发生率比较,差异均无统计学意义(P>0.05)。结论:美托洛尔与参麦注射液联合用于治疗感染性休克,可改善患者血流动力学,减轻炎症反应和心肌损伤,且不会增加心律失常发生风险,安全性良好。
Objective:To investigate the protective effect of Metoprolol combined with Shenmai Injection on myocardial injury in patients with septic shock.Method:From September 2016 to September 2019,100 patients with septic shock in our emergency department were randomly divided into two groups,50 cases in each group.On the basis of basic treatment,the control group was given Metoprolol,the observation group was given Metoprolol combined Shenmai Injection.And the incidence of hemodynamics,myocardial enzymes,inflammatory factors and arrhythmia were compared.Result:After treatment,the heart rate,heart index,myocardial enzyme index and inflammatory factor level of the observation group were lower than those of the control group,and the average arterial pressure and output index of each stroke were higher than those of the control group(P<0.05).There were no significant differences in the incidence of all kinds of arrhythmias between the groups(P>0.05).Conclusion:Metoprolol combined with Shenmai Injection in the treatment of septic shock can improve the hemodynamics,reduce the inflammatory response and myocardial damage,but not increase the risk of arrhythmia.It has good safety.
作者
陈叶华
黄兴伟
廖兴水
CHEN Yehua;HUANG Xingwei;LIAO Xingshui(Mindong Hospital Affiliated to Fujian Medical University,Ningde 355000,China)
出处
《中外医学研究》
2020年第7期40-42,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
