摘要
目的:研究蛋白Z(PZ)、蛋白Z依赖蛋白酶抑制剂(ZPI)及其他凝血指标[蛋白C(PC)、蛋白S(PS)]与妊娠期高血压疾病(HDP)的相关性。方法:收集2017年6月2018年12月在郑州大学第三附属医院产科收治的HDP患者60例作为研究对象(HDP组),其中妊娠期高血压组(25例)、子痫前期组(PE组,35例),另外选取健康孕妇50例作为正常妊娠组,未孕妇女30例作为正常未孕组。比较各组血清PZ、ZPI及血浆PS、PC水平,研究其与HDP的相关性,并采用受试者工作特征(ROC)曲线分析其对HDP的诊断价值。结果:①HDP组的血清PZ、ZPI水平均低于正常妊娠组(P<0.05),正常妊娠组高于正常未孕组(P<0.05),血清PZ、ZPI水平与HDP呈负相关(r分别为-0.687和-0.444,P<0.05),ROC曲线下面积分别为0.901(95%CI:0.853~0.948)、0.759(95%CI:0.676~0.841),最佳诊断截断值分别为31.52 ng/mL和14.54 ng/mL。②血浆PS、PC在HDP组低于正常妊娠组和正常未孕组(P<0.05),正常妊娠组与正常未孕组相比差异无统计学意义(P>0.05),血浆PC水平与HDP呈负相关(r为-0.304,P=0.000),PC对HDP诊断的最佳截断值为108.08%,AUC为0.677(95%CI:0.586~0.769)。血浆PS水平与HDP无相关性(P>0.05)。③HDP组2个亚组相比,PE组血清PZ、ZPI水平均低于妊娠期高血压组(P<0.05),而2组血浆PS、PC水平比较差异无统计学意义(P>0.05)。结论:检测妊娠期高血压疾病患者血清中PZ、ZPI及血浆中PS、PC水平,可以及早地发现凝血指标的异常,进行早期干预治疗,最大程度减少HDP的并发症。
Objective:To study the correlation between protein Z(PZ),protein Z-dependent protease inhibitor(ZPI)and other related blood coagulation indicators(PC,PS)in hypertensive disorders of pregnancy(HDP).Methods:60 cases with HDP were selected from The Third Affiliated Hospital of Zhengzhou University from June 2017 to December 2018 as HDP group(60 cases)and research objects.It was divided into gestation hypertension group(25 cases)and pre-eclampsia group(PE group,35 cases).50 cases pregnancy women were selected as normal pregnancy group and 30 cases not pregnant women were selected as normal non-pregnant group,detect and compare the levels of PZ,ZPI in serum and PS,PC in plasma of each groups of women and investigate the correlation with HDP,evaluate the diagnostic value by ROC curve,analysis its research value for the disease.Results:①The serum PZ and ZPI levels in the HDP group were lower than those in the normal pregnancy group,while the serum PZ and ZPI levels in the normal pregnancy group were higher than those in the normal non-pregnant group(P<0.05).The serum PZ and ZPI levels were negatively correlated with the severity of HDP(P<0.05),the correlation coefficients were-0.687 and-0.444 respectively.The areas under the corresponding ROC curves were 0.901(95%CI:0.853-0.948),0.759(95%CI:0.676-0.841),the cut-off value were 31.52 ng/mL and 14.54 ng/mL respectively.②The plasma PS and PC levels in the HDP group were lower than the other two groups(P<0.05),there was no significant difference between normal pregnancy group and normal non-pregnancy group(P>0.05).The plasma PC levels were negatively correlated with HDP(P<0.05),the correlation coefficients were-0.340.The area under the ROC curve was 0.677(95%CI:0.586-0.769),the cut-off value was 108.08%.The plasma PS level has no correlation with HDP(P>0.05).③In the two subgroups of HDP group,the PZ and ZPI levels in the PE group were lower than those in the gestation hypertension group,there was no significant difference in the levels of PS and PC between the two grou
作者
罗晓华
郭晓珮
黄玉莲
史娜
谷存华
魏心怡
LUO Xiaohua;GUO Xiao-pei;HUANG Yu-lian;SHI Na;GU Cun-hua;WEI Xin-yi(Department of Obstetrics,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《国际妇产科学杂志》
CAS
2020年第2期186-189,共4页
Journal of International Obstetrics and Gynecology
基金
河南省医学科技攻关计划项目(2018020175)。
关键词
高血压
妊娠性
妊娠并发症
心血管
蛋白Z
蛋白Z依赖蛋白酶抑制剂
蛋白S
蛋白C
蛋白酶抑制药
Hypertension
pregnancy-induced
Pregnancy complications
cardiovascular
Protein Z
Protein Z dependent protease inhibitor
Protein S
Protein C
Protease inhibitors
