摘要
背景与目的:通过基于医院登记的局部晚期宫颈癌(locally advanced cervical cancer,LACC)患者的长期随访资料,了解中国LACC患者的长期生存概况。方法:纳入2006—2013年在复旦大学附属肿瘤医院确诊为宫颈癌并接受住院根治术治疗、临床分期为ⅠB2、ⅡA2期、且有随访记录的患者共计1 313例。通过查阅患者复诊病史资料、电话随访及死因数据链接等方式收集生存随访信息,随访统计时间截至2019年11月30日,随访的中位时间为71个月。应用寿命表法估计患者1、3、5和10年总生存率(overall survival,OS)和无病生存率(disease-free survival,DFS),以年龄组、临床分期分层。结果:1 313例LACC患者的平均年龄为45岁,5年OS为77.6%(95%CI:75.1%~80.1%),10年OS为72.5%(95%CI:69.2%~75.7%);5、10年DFS分别为74.0%、71.0%,ⅠB2分期的OS和DFS均高于ⅡA2期,35~44岁的DFS显著高于其他各年龄组。结论:LACC的复发、转移和死亡事件主要发生在治疗后5年内;中国LACC的生存近10年来未见显著变化,LACC年轻患者的临床处理和预后值得关注。
Background and purpose:The study described hospital-based follow-up data of cervical cancer to investigate the long-term survival of locally advanced cervical cancer(LACC)patients in China.Methods:A total of 1313 cases of cervical cancer with clinical stages ofⅠB2 andⅡA2,diagnosed and treated from 2006 to 2013 in Fudan University Shanghai Cancer Center,were included.Medical records review,telephone follow-up and death registry data linkage were applied for collecting follow-up information.The last follow-up date was Nov.30,2019.The median follow-up time was 71 months.Life-table was used to estimate the 1-year,3-year,5-year and 10-year overall survival(OS)rates and disease-free survival(DFS)rates,stratified by age group and clinical stage.Results:The average age of LACC patients was 45 years.The 5-year OS rate was 77.69%(95%CI:75.1%-80.1%),and 10-year OS rate was 72.5%(95%CI:69.2%-75.7%).The 5-year and 10-year DFS rates were 74.0%and 71.0%respectively.Both OS and DFS rates in stageⅠB2 were significantly higher than those in stageⅡA2.DFS rates were significantly different among age groups,with the highest DFS rate observed in 35-44 age group.Conclusion:The recurrence,metastasis and death of LACC mainly occurred within 5 years after treatment.The survival of LACC in China was stable in the past decade.More attention should be paid to clinical management and prognosis for young LACC patients.
作者
沈洁
莫淼
袁晶
周昌明
王泽洲
张志红
温灏
吴小华
郑莹
SHEN Jie;MO Miao;YUAN Jing;ZHOU Changming;WANG Zezhou;ZHANG Zhihong;WEN Hao;WU Xiaohua;ZHENG Ying(Department of Cancer Prevention,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Department of Gynecologic Surgery,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China)
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2020年第3期192-198,共7页
China Oncology
关键词
局部晚期宫颈癌
生存率
医院登记
Locally advanced cervical cancer
Survival rate
Hospital registration
