摘要
目的:探究粪钙卫蛋白(FC)、降钙素原(PCT)、白介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)联合检测及腹部超声诊断新生儿坏死性小肠结肠炎(NEC)的临床价值。方法:选取2018年7月~2019年6月住院的疑似新生儿NEC患儿60例作为研究对象,随机分为对照组和试验组。对照组30例,采用临床诊疗常规手段进行检查与治疗;试验组30例,采用全身及局部炎性因子检测、腹部彩超检查,并根据检查结果进行针对性治疗。两组新生儿另外采用粪便细菌培养检测,并以细菌培养检测结果为金标准,分别对比两组新生儿NEC检测结果,对比阳性率、准确性、灵敏性、特异性以及治疗预后情况。结果:对照组与观察组患者Ramsay评分和BCS评分差异不大,差异无统计学意义(P>0.05),从镇痛剂的使用上来看,观察组患者使用镇痛剂的使用率明显低于对照组,手术后的不良反应发生率明显低于对照组,差异均具有统计学意义(P<0.05)。结论:FC、PCT、IL-6、hs-CRP联合检测及腹部超声诊断可以提高新生儿NEC的临床诊断效果,并对新生儿NEC患儿预后治疗具有较好的预测作用。
Objective:To investigate clinical value of the combined detection of fecal calprotectin(FC),procalcitonin(PCT),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)and abdominal ultrasound in the diagnosis of neonatal necrosis enteric colitis(NEC).Methods:60 infants with suspected neonatal NEC who were hospitalized from July 2018 to June 2019 were selected as research objects and randomly divided into control group and experimental group.The 30 patients in the control group were examined and treated with conventional clinical diagnosis and treatment.The 30 patients in the test group were treated with systemic and local inflammatory factor tests,abdominal color Doppler ultrasonography,and targeted treatment based on the results of the examination.The two groups of neonates were also tested by fecal bacteria culture,and the results were taken as gold standard.The neonatal NEC test results of the two groups were compared,and the positive rate,accuracy,sensitivity,specificity and treatment prognosis were compared.Results:The positive rate of bacterial culture in 30 neonates in the control group was 83.33%,and the positive rate of conventional methods was 56.67%.The positive rate of conventional methods was less than the positive rate of bacterial cultures,and the difference was statistically significant(P<0.05).The positive rate of culture was 90.00%.The positive rate of inflammatory factors combined with abdominal ultrasound diagnosis was 86.67%.Compared with the positive rate of bacterial culture,the difference was not statistically significant(P>0.05).The positive rate,sensitivity,and accuracy of the test group were high.In the control group,the difference was statistically significant(P<0.05).The specificity of the test group was slightly higher than that of the control group,but the difference was not statistically significant(P>0.05).The treatment time of the children in the test group(11.72±2.64)was less At the time of treatment in the control group(16.44±4.25)days,the surgical rate,intestinal sten
作者
杨延江
梁元豪
陈凤娣
王霞
Yang Yanjiang;Liang Yuanhao;Chen Fengdi;Wang Xia(Daocheng Hospital,Dongguan 523176)
出处
《数理医药学杂志》
2020年第4期475-477,共3页
Journal of Mathematical Medicine
基金
东莞市社会科技发展项目(2018507150311291)。
