摘要
胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是小肠L细胞分泌的多肽,具有增加胰岛素的合成和分泌、抑制食欲、延缓胃排空等多种作用。此外,GLP-1在多种组织和器官还具有除葡萄糖控制之外的多种功能。多项研究表明,GLP-1及其类似物可通过抗氧化作用机制,对包括糖尿病在内的多种慢性疾病具有治疗作用。因此,本文以氧化应激为出发点,总结了当前GLP-1的合成与代谢、胰腺和胰腺外效应、糖尿病及其并发症、衰老、神经疾病抗氧化作用等方面的相关进展,旨在为GLP-1相关氧化应激机制的研究和药物研发提供理论参考。
Glucagon-like peptide-1(GLP-1),a polypeptide secreted by small intestinal L cells,has various effects including increasing insulin synthesis and secretion,suppressing appetite,and delaying gastric emptying.In addition to glucose control,GLP-1 has multiple functions in a variety of tissues and organs.A number of studies have shown that GLP-1 receptor agonists could treat a variety of chronic diseases,including diabetes,through antioxidant mechanisms.Based on oxidative stress,this paper summarizes the current progress in the synthesis&metabolism,pancreatic and extracantral effects,anti-oxidation effects of diabetes and its complications,aging,and neurological diseases of GLP-1,with an attempt to provide theoretical reference to researches on related oxidative stress mechanisms and development of new drug.
作者
吴灵灵
孙李丹
WU Lingling;SUN Lidan(Jiaxing University,Jiaxing 314000,China)
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2020年第1期114-120,共7页
Journal of China Pharmaceutical University
基金
国家自然科学基金资助项目(No.81703346)
浙江省公益技术应用研究计划资助项目(No.LGD19H070002)
嘉兴市科技局资助项目(No.2017AY33074)
浙江省大学生科技创新活动计划(新苗人才计划)资助项目(No.2018R417025)
国家级大学生创新创业训练计划资助项目(No.201910354033)
嘉兴学院大学生科研训练计划重点资助项目(No.85178550)。
关键词
GLP-1
GLP-1类似物
氧化应激
glucagon-like peptide-1
glucagon-like peptide-1 analogue
oxidative stress
