摘要
目的分析重症急性胰腺炎(SAP)患者采用早期连续性血液净化(CBP)的抗炎作用和治疗时机.方法将44例重症急性胰腺炎患者依照奇偶数法的分组方式分为对照组和试验组,每组22例,对照组予以常规治疗,试验组予以早期连续性血液净化治疗,比较两组患者的临床疗效.结果试验组患者症状消失时间、体温恢复时间、血淀粉酶恢复时间、肠蠕动恢复时间及住院时间均比对照组明显缩短,组间差异具有统计学意义(P<0.05);与治疗前比较,两组患者治疗后IL-10、IL-6、IL-8、TNF-α等血清细胞因子水平明显降低,且试验组较对照组低,组间差异具有统计学意义(P<0.05);两组患者并发症发生率比较试验组明显低于对照组,差异具有统计学意义(P<0.05);试验组患者的好转率较对照组高,差异具有统计学意义(P>0.05);未愈率、死亡率两组比较差异无统计学意义(P>0.05).结论早期连续性血液净化可显著降低重症急性胰腺炎患者的炎症因子水平,同时可有效改善患者临床症状,减少并发症,促进预后转归.
Objective To analyze the anti-inflammatory effect and treatment timing of early continuous blood purification(CBP) in patients with severe acute pancreatitis(SAP). Method 44 patients with severe acute pancreatitis were divided into control group and experimental group according to the odd and even number method.22 patients in each group were treated with routine treatment,while the experimental group was treated with early continuous blood purification.The clinical efficacy between the two groups was compared.Results The symptoms disappearance time,temperature recovery time,blood amylase recovery time,intestinal peristalsis recovery time and hospitalization time in the experimental group were significantly shorter than those in the control group(P<0.05);comparing with before treatment,the levels of serum cytokines such as IL-10,IL-6,IL-8 and TNF-alpha in the two groups after treatment were significantly lower,and the experimental group was lower than the control group. There were significant differences between the two groups(P < 0. 05). Comparing the incidence of complications between the two groups,the experimental group was significantly lower than the control group(P<0.05).The improvement rate of the experimental group was higher than that of the control group,and the difference between the two groups was significant(P > 0. 05). The unhealed rate and mortality rate did not show statistical significance between two groups(P>0.05).Conclusion Early continuous blood purification can significantly reduce the level of inflammatory factors in patients with severe acute pancreatitis,and effectively improve clinical symptoms,reduce complications and promote prognosis.
作者
王雪英
刘艳红
WANG Xueying;LIU Yanhong(Affiliated Hospital of Beihua University,Jilin 132011,China)
出处
《北华大学学报（自然科学版）》
CAS
2020年第2期223-226,共4页
Journal of Beihua University（Natural Science）
基金
吉林市科技局科技计划项目(2013R014).
关键词
重症急性胰腺炎
早期连续性血液净化
治疗时机
抗炎作用
severe acute pancreatitis
early continuous blood purification
treatment timing
anti-inflammatory effect
