摘要
目的探讨体检人群幽门螺杆菌(Hp)感染情况以及与同型半胱氨酸(Hcy)、代谢综合征(MS)之间的关系,为Hp感染的防治和相关疾病诊疗提供依据。方法以健康体检者3 551例作为对象,进行14C-尿素试验测定Hp,检测空腹血糖、血脂和Hcy水平,采用SPSS 18.0统计软件分析Hp的感染率,Hp感染组与非感染组代谢指标的比较,多因素logistic回归分析Hp与Hcy、MS的关系。结果 (1)体检人群Hp感染率40.7%(1 445/3 551),男性感染率25.3%(898/3 551),女性感染率15.4%(547/3 551),男性感染率高于女性,男性、女性组间差异无统计学意义(P>0.05)。(2)Hp感染组血清Hcy浓度和高同型半胱氨酸血症(HHcy)检出率均高于非感染组(P<0.05)。(3)Hcy和MS是Hp感染的独立危险因素(P<0.05)。结论 Hcy、MS均为Hp感染的独立危险因素。
Objective To investigate the prevalence of helicobacter pylori(Hp) infection and its correlations with homocysteine(Hcy) and metabolic syndrome(MS) in physical examination population, so as to provide evidence for the prevention and treatment of Hp infection and related diseases. Methods A total of 3551 health examinees from the medical examination center of Affiliated Hospital of Guilin Medical College in 2018 were tested for Hp infection by 14C-urea test. The levels of fasting blood glucose, lipid and Hcy were measured. The infection rate of Hp was analyzed by SPSS18.0 statistical software. The levels of fasting blood glucose, lipid and Hcy were measured. The metabolic indicators were compared between infected and non-infected groups. Multivariate logistic regression was used to analyze the correlations between Hp infection and Hcy or MS. Results The total infection rate of Hp was 40.7%(1 445/3 551), 25.3%(898/3 551) in males, and 15.4%(547/3 551) in females. The infection rate in males was higher than that in females, and there was no significant difference in infection rate among ages and genders(P>0.05). The serum concentration of Hcy and the detection rate of Hcy in the infected group were significantly higher than those in the non-infected group(P<0.05). Hcy and MS were independent risk factors for Hp infection(P<0.05). Conclusion Hp infection is positively correlated with Hcy and MS.
作者
杨波
刘升学
王彩梅
刘春雨
于健
YANG Bo;LIU Sheng-xue;WANG Cai-mei;LIU Chun-yu;YU Jian(Physical Examination Center of Affiliated Hospital of Guilin Medical College,Guilin 541001,Guangxi,China)
出处
《广东医学》
CAS
2020年第4期365-369,共5页
Guangdong Medical Journal
基金
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190303)。
