摘要
异位骨化是指在非骨骼组织(包括肌肉,肌腱或其他软组织)中出现病理性骨组织形成。其发病机制尚不完全清楚,主要是由骨骼肌肉创伤、骨关节术后或者神经系统损伤所导致,临床表现以关节肿胀、疼痛、活动障碍为主,多发生于髋、膝和肘关节周围。目前对异位骨化预防主要包括药物、放疗、分子生物学机制干预和中医药相关手段。其中药物及放疗是预防异位骨化较为肯定有效的方法。而通过分子生物学机制干预预防异位骨化成为近年来新的研究方向和关注热点,且基本处于实验研究阶段。而关于异位骨化的治疗主要包括药物、物理治疗及手术等多种方法,其中手术是被公认的最有效的治疗手段,但关于手术时间和术式的选择尚存在一定争议和分歧。
Heterotopic ossification is the formation of pathological bone in non-skeletal tissues(including muscles,tendons or other soft tissues),and the pathogenesis is not completely clear.It is often caused by musculoskeletal trauma,postoperative bone and joint surgery,or damage of the nervous system,the clinical manifestations are joint swelling,pain,and movement disorders,which often occur around the hips,knees,and elbows.At present,the prevention of heterotopic ossification mainly includes drugs,radiotherapy,molecular biological mechanism intervention,and Chinese medicine-related measures.Among them,drugs and radiotherapy are more effective methods to prevent heterotopic ossification.The intervention of molecular biology mechanism to prevent heterotopic ossification has become a new research direction and focus of attention inrecent years,and is basically at the experimental research stage.The treatment of heterotopic ossification includes various methods such as drugs,physical therapy,and surgery.Among them,surgery is recognized as the most effective treatment,however there are still some controversies and disagreements about the choice of operation time and surgical methods.
作者
曾林如
罗淦
朱芳兵
王建岳
侯桥
岳振双
严世贵
全仁夫
章英良
ZENG Lin-ru;LUO Gan;ZHU Fang-bing;WANG Jian-yue;HOU Qiao;YUE Zhen-shuang;YAN Shi-gui;QUAN Ren-fu;ZHANG Ying-liang(Department of Foot and Ankle Surgery,Xiaoshan District Hospital of TCM,Affiliated Jiangnan Hospital of Zhejiang Chinese Medicine University,Hangzhou 311201,Zhejiang,China)
出处
《中国骨伤》
CAS
CSCD
2020年第3期283-287,共5页
China Journal of Orthopaedics and Traumatology
关键词
异位骨化
预防
治疗
综述
Heterotopic ossification
Prevention
Treatment
Review
