摘要
目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者Ⅰ型胶原氨基端前肽(N-terminal propeptide of typeⅠprocollagen,PⅠNP)、Ⅰ型胶原羧基端肽β特殊序列(β-Cterminal telopeptide of typeⅠcollagen,β-CTX)水平与骨密度降低的关系。方法:选取COPD患者80例,分为COPD急性加重组40例与COPD稳定组40例,选取同期在本院体检的健康人群40例作为对照组,采用双能X射线骨密度检测仪测量所有对象的骨密度,测定并比较血清中骨代谢指标PⅠNP、β-CTX的水平。结果:COPD急性加重组与COPD稳定组骨质疏松发生率均明显高于对照组(P<0.001)。COPD急性加重组与COPD稳定组血清β-CTX水平较对照组均显著升高,且COPD急性加重组高于COPD稳定组,差异均有统计学意义(P<0.05);而COPD急性加重组与COPD稳定组血清PⅠNP水平、PⅠNP/β-CTX比值均低于对照组(P<0.01)。结论:COPD患者,尤其是急性加重期的患者,骨吸收功能异常活跃,新骨形成速度减慢,骨量丢失明显增加,从而存在较高的继发骨质疏松的风险。
Objective:To investigate the correlation between N-terminal propeptide of type I procollagen(PⅠNP)andβ-C-terminal telopeptide of type I collagen(β-CTX)and low bone mineral density in patients with chronic obstructive pulmonary disease(COPD).Method:A total of 80 COPD patients were selected,they were divided into 40 patients with acute exacerbation of COPD group and 40 patients with stable COPD group,40 cases healthy people were selected as the control group.We detected the bone mineral density by dual energy X-ray absorptiometry,and the levels of PⅠNP andβ-CTX were measured.Result:The prevalence of osteoporosis in acute exacerbation of COPD group and stable COPD group were significantly higher than those in the control group(P<0.001).Compared with the control group,the levels ofβ-CTX in acute exacerbation of COPD group and stable COPD group were significantly higher,and the levels of acute exacerbation of COPD group were higher than those in the stable COPD group(P<0.05).The levels of PⅠNP and the ratio of PⅠNP/β-CTX in acute exacerbation of COPD group and stable COPD group were significantly lower than those in the control group(P<0.01).Conclusion:The bone resorption function of patients with COPD,especially in the acute exacerbation period,is extremely active,and the bone mass loss increases obviously,the bone formation become slowly,and which may increase the risk of secondary osteoporosis.
作者
陈嘉馨
李映梅
刘志宝
黄汉培
张志海
谭慧锋
许健辉
CHEN Jiaxin;LI Yingmei;LIU Zhibao;HUANG Hanpei;ZHANG Zhihai;TAN Huifeng;XU Jianhui(Nanhai Hospital of the People’s Hospital of Guangdong Province,Foshan 528251,China)
出处
《中国医学创新》
CAS
2020年第9期133-136,共4页
Medical Innovation of China
基金
佛山市科技攻关项目(2017AB000112)。
关键词
慢性阻塞性肺疾病
Ⅰ型胶原氨基端前肽
Ⅰ型胶原羧基端肽β
特殊序列
骨密度
Chronic obstructive pulmonary disease
N-terminal propeptide of type Ⅰ procollagen
β-Cterminaltelopeptide of type Ⅰ collagen
Bone mineral density
