摘要
目的:采用Meta分析的方法综合系统地评价HBsAg阳性母亲服用替比夫定阻断HBV母婴传播的疗效。方法:通过检索CNKI、万方、Pubmed、CBM等数据库收集相关文献,采用Rev Man 5.3软件进行Meta分析。结果:纳入13篇文献研究,替比夫定组孕妇共1003例,对照组孕妇共1060例。Meta分析结果显示,替比夫定组孕妇分娩前HBV DNA水平明显低于对照组,差异有统计学意义(P<0.01);替比夫定组出生不同时间的婴儿HBsAg阳性率及HBV DNA阳性率均低于对照组(P<0.05)。结论:Meta分析结果显示,替比夫定可以有效地阻断HBV母婴传播。
Objective:To evaluate the effect of Telbivudine treatment on blocking mother-to-child transmission of HBV in HBsAg positive mothers by Meta analysis.Method:Literatures were retrieved from CNKI,Wanfang,Pubmed,CBM databases,and so on.Rev Man 5.3 was adopted to carry out Meta analysis.Result:Finally,13 articles were included in the study.There were 1003 pregnant women in the Telbivudine group and 1060 pregnant women in the control group.The results of Meta analysis showed that the HBV DNA level of pregnant women in Telbivudine group was significantly lower than that of control group before delivery,the difference was statistically significant(P<0.01);the HBsAg positive rate and HBV DNA positive rate in the Telbivudine group were lower than those in the control group at different time after birth,the differences were statistically significant(P<0.05).Conclusion:The results of Meta analysis showed that Telbivudine could effectively block mother-to-child transmission of HBV.
作者
温海秀
张兴
高淑红
师先锋
WEN Haixiu;ZHANG Xing;GAO Shuhong;SHI Xianfeng(Statistics Teaching and Research Department in Fenyang College of Shanxi Medical University,Fenyang 032200,China)
出处
《中国医学创新》
CAS
2020年第3期166-172,共7页
Medical Innovation of China
基金
山西医科大学汾阳学院校级科研基金(2018D07)。
关键词
替比夫定
母婴传播
META分析
Telbivudine
Mother-to-child transmission
Meta analysis
