摘要
目的:观察龙胆泻肝汤治疗湿热瘀结型盆腔炎性不孕的临床疗效,并探讨其治疗的作用机制。方法:选择湖南中医药大学第一附属医院2017年1月至2018年12月收治的150例湿热瘀结型盆腔炎性不孕患者为研究对象,按照随机数字表法分为对照组和观察组,每组75例,对照组给予抗生素联合肝胆双清颗粒治疗,观察组给予龙胆泻肝汤联合抗生素治疗,两组均连续治疗6周。比较两组患者的临床疗效、中医证候积分、血液流变学及血清生化指标、炎症因子水平和免疫功能指标。结果:观察组总有效率93. 33%(70/75),高于对照组的78. 67%(59/75)(χ~2=6. 480,P <0. 05)。观察组妊娠率58. 33%,显著高于对照组的33. 82%(χ~2=8. 862,P <0. 01)。治疗前两组患者的中医证候积分、血液流变学及血清生化指标、炎症因子水平和免疫功能指标差异无统计学意义。与本组治疗前比较,治疗后两组患者下腹腹痛、肛门坠胀、腰骶疼痛、带下异常和月经失调等中医证候积分降低(P <0. 05);血液流变学指标血浆黏度、红细胞积压、全血黏度高切和低切水平降低(P <0. 05);抑制素-A(INH-A)水平升高,孕酮(P)和β-绒毛膜促性腺激素(β-HCG)水平降低(P <0. 05);血清C-反应蛋白(CRP),白细胞介素-6(IL-6)和肿瘤坏死因子(TNF)-α水平降低(P <0. 05);CD4^+和CD8^+水平升高(P <0. 05);免疫球蛋白(Ig) A,Ig G,Ig M水平降低(P <0. 05)。与对照组治疗后比较,观察组下腹腹痛、肛门坠胀、腰骶疼痛、带下异常和月经失调等中医证候积分降低,血液流变学指标血浆黏度、红细胞积压、全血黏度高切和低切水平降低,INH-A水平升高,P和β-HCG水平显著降低,血清CRP,IL-6和肿瘤坏死因子(TNF-α)水平显著降低,CD4^+和CD8^+水平升高,Ig A,Ig G和Ig M水平降低(P <0. 05)。两组患者在治疗期间未见明显不良反应。结论:龙胆泻肝汤治疗湿热瘀结型盆腔炎性不孕具有较好的临床疗效,可降�
Objective: To observe the clinical efficacy of Longdan Xiegantang in the treatment of pelvic inflammatory infertility with damp-heat phlegm and phlegm,in order to explore its mechanism of action. Method:Totally 150 patients with phlegm and inflammatory pelvic inflammatory infertility admitted to First Hospital of Hunan University of Chinese Medicine from January 2017 to December 2018 were enrolled in the study. According to the random number,the patients were divided into control group and observation group,with 75 cases in each group.Control group was given antibiotics combined with Gandan Shuangqing granule,and observation group was given Longdan Xiegantang combined with antibiotics. Both groups were treated for 6 weeks. The clinical efficacy,traditional Chinese medicine( TCM) syndrome scores, blood rheology and serum biochemical parameters,inflammatory factor levels and immune function indexes of the two groups were compared. Result: The total effective rate of observation group was 93. 33%,which was higher than 78. 67% of control group( χ~2= 6. 480,P <0. 05). The pregnancy rate of observation group was 58. 33%,which was significantly higher than 33. 82% of control group( χ~2= 8. 862,P < 0. 01). Before treatment,there was no significant difference in TCM syndrome score,hemorheology,serum biochemical index,inflammatory factor level and immune function between the two groups. Compared with before treatment, the TCM syndrome scores of lower abdominal pain, anal bulge,lumbosacral pain,abnormal bandage and menstrual disorders were significantly reduced,the levels of plasma viscosity,hematocrit,high and low-shear whole blood viscosity were significantly reduced,the level of inhibin-A( INH-A) was significantly increased,the level of progesterone( P) and beita chorionic gonadotropin( β-HCG)were significantly reduced,the levels of serum C-reactive protein( CRP),interleukin-6( IL-6) and tumor necrosis factor-α( TNF-α) were significantly decreased,the levels of CD4^+ and CD8^+ were significantly increased,and the le
作者
李姣
林洁
LI Jiao;LIN Jie(The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第6期85-90,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
湖南省教育厅科学研究项目(2017B195)。
关键词
盆腔炎性不孕
湿热瘀结
龙胆泻肝汤
血液流变学
血清生化
炎症因子
免疫功能
pelvic inflammatory infertility
damp-heat phlegm
Longdan Xiegantang
blood rheology
serum biochemistry
inflammatory factor
immune function
