摘要
目的:系统梳理《金匮要略》鳖甲煎丸的历代衍变情况、古今临床应用情况,并分析其在现代的应用转化情况,一方面为鳖甲煎丸的二次开发提供思路,另一方面为经典名方的转化和应用提供参考。方法:搜集与整理鳖甲煎丸的古代文献与现代文献,对鳖甲煎丸的古代及现代临床应用情况进行梳理,研究其源流、方义衍变及主治病证变化情况。结合市场调研,对鳖甲煎丸的市场转化情况进行分析,分析其研发过程及市场应用情况。结果:自《金匮要略》后,鳖甲煎丸在历代均有流传,但其变化不大,治疗疾病单一,为治疟母的专方。从药物剂量比来看,鳖甲煎丸中鳖甲和赤硝为主药,并重用虫类药。现代文献分析发现,鳖甲煎丸无论是临床研究还是实验研究,均主要用于治疗肝纤维化、肝硬化、肝癌等肝脏疾病。调研发现,鳖甲煎丸在由经方转化为中成药时,其思路基本为"尊古",其组成、用量、制法等基本遵循了《金匮要略》中原方的记载。中成药制剂已被收录于多个疾病诊疗、用药指南及专家共识中。对比其他抗肝纤维化的中成药,鳖甲煎丸的临床应用较广,成本较低。结论:鳖甲煎丸在古代为治疗疟母的专方,现代则多用来治疗肝纤维化等肝脏疾病,疗效确切。此外,鳖甲煎丸已成功地转化为现代中成药制剂,并在市场上得到较好的反应,为其他经典名方的转化和应用提供了参考。
Objective: To systematically review the evolution of Biejia Jianwan in Medical Treasures of the Golden Chamber and its clinical application in ancient and modern times,in order to analyze its application and transformation in modern times. For one thing,it provided ideas for the secondary development of Biejia Jianwan,for another,it provided reference for the transformation and application of classical famous prescriptions. Method:Ancient and modern literature of Biejia Jianwan were collected and summarized to study the ancient and modern clinical application of Biejia Jianwan,and its origin,evolution of prescription meanings and changes of main indications. Based on market research, the market transformation of Biejia Jianwan, and its research and development process and market application were analyzed. Result: Biejia Jianwan has been applied in past dynasties since the Medical Treasures of the Golden Chamber,but with insignificant changes and simple indications.In fact,Biejia Jianwan was specially developed for the treatment of malaria with abdominal mass. According to the drug dosage ratio,Trinycis Carapax and Chixiao are the main drugs in Biejia Jianwan,and insect drugs are also used. Modern literature analysis shows that Biejia Jianwan is mainly used to treat liver diseases,such as liver fibrosis,cirrhosis and liver cancer,whether in clinical or experimental studies. It was found that when Biejia Jianwan was transformed from a classical prescription into a Chinese patent medicine mainly based on its composition,dosage and preparation of the original prescription recorded in the Medical Treasures of the Golden Chamber. Chinese patent medicine preparations have been included in many diseases diagnosis and treatment,medication guidelines and expert consensus. Compared with other traditional Chinese medicines,Biejia Jianwan is more widely used in clinic with lower costs. Conclusion: Biejia Jianwan is used to treat malaria with abdominal mass in ancient times,but in modern times it is mostly used to treat liver
作者
刘思鸿
李莎莎
侯酉娟
李斌
董燕
李兵
LIU Si-hong;LI Sha-sha;HOU You-juan;LI Bin;DONG Yan;LI Bing(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第6期12-17,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中央级公益性科研院所基本科研业务费专项(ZZ120304)
已上市经典名方数据库的构建与评价研究项目(ZZ110320)
历代医家知识库构建与学术流派时空衍变研究项目(ZC201807)。
关键词
鳖甲煎丸
临床应用
文献研究
《金匮要略》
中成药
Biejia Jianwan
clinical application
literature research
Medical Treasures of the Golden Chamber
Chinese patent medicine
