摘要
目的探讨盐酸川芎嗪注射液联合单唾液酸四己糖神经节苷脂钠注射液治疗小儿脑瘫的疗效与安全性。方法选取2017年1月~2019年4月我院新诊断脑瘫患儿80例,按随机数字表法分为观察组和对照组,每组40例。对照组给予单唾液酸四己糖神经节苷脂钠注射液治疗,观察组在此基础上给予盐酸川芎嗪注射液治疗。观察基线期与治疗后两组GMFM和CDRS评分的变化,比较两组临床疗效和不良反应发生情况。结果观察组临床疗效有效率显著高于对照组,差异有统计学意义(P<0.05)。基线期,观察组GMFM和CDRS评分比较,差异无统计学意义(P>0.05);治疗后,观察组GMFM和CDRS评分显著高于对照组,差异有统计学意义(P<0.05);治疗后两组GMFM和CDRS评分均显著高于基线期,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论与单纯单唾液酸四己糖神经节苷脂钠注射液相比,在此基础上联用盐酸川芎嗪注射液能改善脑瘫患儿粗大运动功能和综合功能,且未增加不良反应发生率。
Objective To explore curative effects and safety of tetramethylpyrazine hydrochloride injection combined with monosialotetrahexosylganglioside sodium injection in treatment of infantile cerebral palsy.Methods 80 children who were diagnosed as cerebral palsy in our hospital from January 2017 to April 2019 were selected.According to the random number table method,they were divided into the observation group and the control group,with 40 cases in each group.The control group was treated with monosialotetrahexosylganglioside sodium injection while the observation group was treated with tetramethylpyrazine hydrochloride injection on basis of it.Changes in GMFM and CDRS scores at baseline and after treatment of two groups were observed.The clinical curative effects and adverse reactions of the two groups were compared.Results The clinical effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).At baseline,there was no statistically significant difference in GMFM and CDRS scores between the observation group and the control group(P>0.05).After treatment,GMFM and CDRS scores of the observation group were significantly higher than the control group,and the difference was statistically significant(P<0.05).After treatment,the GMFM and CDRS scores of the two groups were significantly higher than the baseline period,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with monosialotetrahexosylganglioside sodiun injection alone,combination with tetramethylpyrazine hydrochloride injection can improve the gross motor function and comprehensive function of children with cerebral palsy without increasing the incidence of adverse reactions.
作者
陈文婷
张美华
赖永娥
CHEN Wenting;ZHANG Meihua;LAI Yong'e(Department of Pharmacy,Chancheng District Central Hospital,Guangdong,Foshan 528000,China)
出处
《中国医药科学》
2020年第2期63-65,121,共4页
China Medicine And Pharmacy
关键词
盐酸川芎嗪注射液
单唾液酸四己糖神经节苷脂钠注射液
脑瘫
婴儿
幼儿
Tetramethylpyrazine hydrochloride injection
Monosialotetrahexosylganglioside sodiun injection
Cerebral palsy
Infant
Children
