摘要
目的研究肠道微生态重建疗法治疗肠易激综合征的效果。方法将200例肠易激综合征患者随机分为对照组和重建组,剔除失访病例后共164例有效病例,其中对照组83例,重建组81例,对照组予以双歧杆菌三联活菌和复合乳酸菌治疗2周,重建组予以重建肠道微生态疗法1周,采用胃肠道症状量表评估患者治疗前、治疗后1、3、6个月的症状改善情况,并采用肠易激综合征生活质量专用量表(IBS-QOL)评估患者治疗前后的生活质量。结果重建组治疗后1个月临床症状改善有效率(86.42%)与对照组(77.11%)比较,差异无统计学意义(P>0.05);重建组治疗后3、6个月(75.31%、60.49%)均高于对照组(60.24%、38.55%),差异有统计学意义(P<0.05);治疗后两组生活质量评分均降低,但重建组比对照组更低,差异有统计学意义(P<0.05)。结论重建肠道微生态疗法可以有效改善肠易激综合征患者的临床症状,并可提高中远期疗效和患者生活质量,具有较好的临床应用价值。
Objective To study the effect of intestinal microecological reconstruction in the treatment of irritable bowel syndrome.Methods 200 patients with irritable bowel syndrome were randomly divided into the control group and the reconstruction group.After excluding the lost follow-up cases,there were 164 effective cases,including 83 cases in the control group and 81 cases in the reconstruction group.The control group was treated with bifidobacteria triple viable bacteria and combined lactic acid bacteria for 2 weeks,while the reconstruction group was treated with intestinal microecological therapy for 1 week.Gastrointestinal symptoms scale was used to evaluate the improvement of symptoms before and 1 month,3 months and 6 months after treatment,and IBS-QOL was used to evaluate the quality of life of patients before and after treatment.Results 1 month after treatment,the effective rate of improvement in clinical symptoms in the reconstruction group(86.42%)and the control group(77.11%)showed no statistically significant difference(P>0.05).The values in reconstruction group were 75.31%and 60.49%,higher than those in the control group(60.24%,38.55%,respectively)at 3 and 6 months after treatment(P<0.05).After treatment,the quality of life scores of both groups decreased,but the reconstruction group was lower than the control group,with statistically significant difference(P<0.05).Conclusion Reconstruction of intestinal microecology therapy can effectively improve the clinical symptoms of irritable bowel syndrome patients,and improve the medium and longterm efficacy and the quality of life of patients,with good clinical value.
作者
肖文
尹泉
赵超
谢彩红
陈冬妹
XIAO Wen;YIN Quan;ZHAO Chao;XIE Caihong;CHEN Dongmei(Gastroenterology Department,Boai Hospital of Zhongshan,Guangdong,Zhongshan 528403,China)
出处
《中国医药科学》
2020年第3期238-240,共3页
China Medicine And Pharmacy
基金
广东省中山市社会公益科技研究项目(2016B1077)。
关键词
肠道微生态
益生菌
肠易激综合征
菌群定植
Intestinal microecology
Probiotics
Irritable bowel syndrome
Microbes colonize
