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ANC及免疫功能变化与妇科术后淋巴囊肿并发感染的关系研究 被引量:6

Relationship between ANC and immune function changes and concurrent infection of lymphocytic cysts afer gynecological surgery
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摘要 目的探讨中性粒细胞绝对数(ANC)及免疫功能变化与妇科术后淋巴囊肿并发感染的关系,为妇科术后淋巴囊肿并发感染的防治提供参考。方法选取2018年1-12月于郑州人民医院行盆腔淋巴结清扫术后发生淋巴囊肿的患者100例为研究对象,对淋巴囊液进行病原菌检测,同时检测患者血ANC及血清免疫球蛋白A(IgA)、IgG、IgM、T细胞亚群(CD3^+、CD4^+、CD8^+)绝对计数及CD4^+/CD8^+。结果27例患者发生囊肿并发感染,感染率为27.00%,其中21例患者囊液检测出病原菌21株,其中葡萄球菌属10株、链球菌属6株、肠球菌属3株、其他2株;感染患者ANC、IgA、IgG、IgM、CD3^+、CD4^+、CD4^+/CD8^+水平分别为(0.65±0.23)×10^9/L、(3.28±2.11)g/L、(9.70±1.72)g/L、(1.26±0.68)g/L、(41.21±4.38)%、(32.11±4.15)%、(1.07±0.43)均低于无感染患者,CD8^+(30.33±2.89)%高于无感染患者(P均<0.001);ANC、CD4^+/CD8^+水平低下是妇科术后淋巴管囊肿患者并发感染的影响因素(P<0.05)。结论妇科术后囊肿患者ANC及免疫功能低下时易发生囊肿并发感染,应针对引起术后淋巴囊肿并发感染的因素进行防控,若患者存在ANC及免疫功能低下应积极纠正,以避免并发感染。 OBJECTIVE To investigate the relationship between absolute neutrophil count(ANC)and immune function changes and infection of lymphocytic cysts after gynecological surgery,so as to provide reference for the prevention and treatment of lymphatic cysts complicated with infection after gynecological surgery.METHODS A total of 100 patients with lymphocysts after pelvic lymphadenectomy at Zhengzhou People’s Hospital from Jan.to Dec.2018 were selected as study subjects.The lymphocyst fluid was detected for pathogenic bacteria,and blood ANC,serum immunoglobulin A(IgA),IgG,IgM,the absolute counts of T cell subsets(CD3^+,CD4^+,CD8^+)and CD4^+/CD8^+were also detected.RESULTS Totally 27 patients had concurrent infection,the infection rate was 27.00%.Among them,21 strains of pathogenic bacteria were detected in the lymphocyst fluid of 21 patients,including 10 strains of Staphylococcus,6 strains of Streptococcus,3 strains of Enterococcus and 2 strains of others.The levels of ANC,IgA,IgG,IgM,CD3^+,CD4^+,and CD4^+/CD8^+in patients with infection were(0.65±0.23)×10^9/L,(3.28±2.11)g/L,(9.70±1.72)g/L,(1.26±0.68)g/L,(41.21±4.38)%,(32.11±4.15)%,and(1.07±0.43),respectively,lower than those in patients without infection.The CD8^+levels in patients with infection were(30.33±2.89)%,significantly higher than that in patients without infection(P<0.001).Low ANC and CD4^+/CD8^+levels were the influencing factorsof concurrent infection in patients with lymphangitic cysts after gynecological operation(P<0.05).CONCLUSION Gynecological postoperative cysts patients were prone to cystic infections when ANC and immune function were low.The factors that cause postoperative lymphocystic infections should be prevented and controlled.If the patients had ANC and immunocompromised,they should be actively corrected to avoid concurrent infection.
作者 程劼 张晓利 宋晓霞 张占新 蕾娜 刘春喜 CHENG Jie;ZHANG Xiao-li;SONG Xiao-xia;ZHANG Zhan-xin;LEI Na;LIU Chun-xi(Zhengzhou People's Hospital,Zhengzhou,Henan 450003,China;不详)
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2020年第4期577-580,共4页 Chinese Journal of Nosocomiology
关键词 中性粒细胞绝对数 免疫球蛋白 T细胞亚群 淋巴囊肿 感染 妇科手术 Absolute neutrophil count Immunoglobulin T cell subsets Lymphocyst Infection Gynecologic surgery
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