摘要
目的:观察加味逍遥散联合三维适形放疗对原发性肝癌(PLC)患者血清肝细胞生长因子(HGF)、转化生长因子-β1(TGF-β1)及免疫功能的影响。方法:选取90例PLC患者为研究对象,按照随机数字表法分为观察组和对照组,每组45例。对照组采用经肝动脉化疗栓塞术(TACE)联合三维适形放疗治疗,观察组在对照组基础上联合加味逍遥散治疗。对比2组中医证候疗效和实体瘤疗效,观察治疗前后血清HGF、TGF-β1及免疫功能指标的变化,记录不良反应发生情况。结果:观察组中医证候改善率97.78%,高于对照组的77.78%,差异有统计学意义(P<0.05)。观察组实体瘤疗效有效率略高于对照组,差异无统计学意义(P>0.05)。与治疗前比较,治疗后2组HGF水平均升高(P<0.05),TGF-β1水平均降低(P<0.05),观察组2项指标水平升高或降低幅度均大于对照组(P<0.05)。与治疗前比较,治疗后2组CD3^+、CD4^+、CD4^+/CD8^+、自然杀伤细胞(NK细胞)值均升高(P<0.05),观察组以上4项指标值均高于对照组(P<0.05)。2组治疗过程中均无严重不良反应发生。结论:加味逍遥散联合三维适形放疗治疗PLC可提高临床疗效,改善患者的免疫功能,调节机体血清相关因子。
Objective: To observe the effect of modified Xiaoyao powder combined with three-dimensional conformal radiotherapy on serum hepatocyte growth factor(HGF), transformed growth factor-β1(TGF-β1) and immune function in patients with primary liver cancer(PLC). Methods:A total of 90 cases of PLC patients were divided into the observation group and the control group according to the random number table, 45 cases in each group. Both groups were treated with transcatheter arterial chemoembolization(TACE) combined with three-dimensional conformal radiotherapy and the observation group was additionally given modified Xiaoyao powder. The curative effect of Chinese medicine syndrome and solid tumors in the two groups were compared;the changes of the indexes of serum HGF,TGF-β1 and immune function before and after treatment were observed and the occurrence of adverse reactions was recorded. Results:The improvement rate of Chinese medicine syndrome in the observation group was 97.78%,being higher than that of 77.78% in the control group,difference being significant(P<0.05). The effective rate of the curative effect of solid tumor in the observation group was slightly better than that in the control group,but there was no significant difference being found(P>0.05). After treatment,HGF levels in the two groups were increased when compared with those before treatment(P<0.05),TGF-β1 levels were decreased(P<0.05),and the increasing or decreasing amplitude of the levels of the two indexes in the observation group was larger than that in the control group(P<0.05). After treatment,the cell values of CD3^+,CD4^+,CD4^+/CD8^+ and NK in the two groups were all increased when compared with those before treatment(P<0.05), and the increasing amplitude of the four index values mentioned above in the observation group was larger than that in the control group(P<0.05). There were no severe adverse reactions being found in the two groups during the course of treatment. Conclusion: The application of modified Xiaoyao powder combined with three
作者
徐彩霞
李德
倪玲琴
刘艳梅
虞希祥
XU Caixia;LI De;NI Lingqin;LIU Yanmei;YU Xixiang
出处
《新中医》
CAS
2020年第4期26-29,共4页
New Chinese Medicine
基金
温州市科学技术局项目(Y20140390)。
