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优秀长跑运动员NADPH氧化酶p22phox亚基基因多态性分子标记的探讨

Feasibility study of using SNPs in the NADPH oxidase p22phox gene as molecular marker for talent selection of long-distance runner
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摘要 目的:解析NADPH氧化酶p22 phox(NADPH Oxidase p22phox,CYBA)基因的C242T、A930G和A675T多态位点,探讨用于我国北方汉族优秀长跑运动员分子选材标记的可行性。方法:选取优秀长跑运动员123人作为运动员组,127名中国北方汉族普通大学生为对照组,采用基质辅助激光解吸附电离飞行时间质谱检测技术,对CYBA基因的C242T、A930G和A675T位点进行解析并分析比较。结果:与对照组相比,运动员组A930G和A675T位点的基因型和等位基因频率均无显著性差异(P>0.05),而C242T位点的TC基因型在5 km/10 km运动员组的分布频率存在显著性差异(P<0.05)。结论:C242T位点的TC基因型可作为5 km/10 km优秀运动员选材的分子标记。
作者 周文婷 胡扬 ZHOU Wen-ting;HU Yang
出处 《中国应用生理学杂志》 CAS CSCD 北大核心 2019年第6期506-510,共5页 Chinese Journal of Applied Physiology
基金 国家自然科学基金(31071032) 2018年度黑龙江省省属高等学校基本科研业务费科研项目(2018KYYWF-FC07) 2018年黑龙江省教育厅“冰雪运动学”特色学科专项重点项目(BXZD001)。
关键词 NADPH氧化酶p22phox基因 基因多态性 长跑运动员 遗传标记 CYBA polymorphisms long-distance runner genetic mark
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  • 1Yong Yong SHI,Lin HE.SHEsis,a powerful software platform for analyses of linkage disequilibrium,haplotype construction,and genetic association at polymorphism loci[J].Cell Research,2005,15(2):97-98. 被引量:382
  • 2Lewontin R. On measures of gametic disequilibrium. Genetics 1988; 120:849-52. 被引量:1
  • 3Chen WY, Shi YY, Zheng YL, et al. Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8. Hum Mol Genet 2004; 13:2991-5. 被引量:1
  • 4Shi Y, Zhao X, Yu L, et al. Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population. Genome Res 2004; 14:1345-9. 被引量:1
  • 5Zhao X, Shi Y, Tang J, et al. A case control and family based association study of the neuregulinl gene and schizophrenia. J Med Genet 2004; 41:31-4. 被引量:1
  • 6Guo S, Shi Y, Zhao X, et al. No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population. Neurosci Lett 2004; 369:168-72. 被引量:1
  • 7Yang MS, Yu L, Guo TW, et al. Evidence for association between single nucleotide polymorphisms in T complex protein 1 gene and schizophrenia in the Chinese Han population. J Med Genet 2004; 41:e63. 被引量:1
  • 8Galaris D, Barhouti A, Korantzopoulos P. Oxidative stress in hepatic ischemia-rcperfusion injury: the role of antioxidants and iron chelating compounds [J]. Curr Pharm Des, 2006,12 : 2875-2890. 被引量:1
  • 9Takada Y, Mukhopadhyay A, Kundu G C. Mahabeleshwar G H,Singh S, Aggarwal B B. Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involve-ment of I kappa B alpha kinase and Syk protein-tyrosine kinase [J]. J Biol Chem.2003.278:2433-2111. 被引量:1
  • 10Oida Y.Gopalan B, Miyahara R,Branch C D.Chiao P,Chada S, et al. Inhibition of nuclear factor-kappaB augments antitumor activity ofadenovirus-mediated melanoma differentiation-associated gene-7 against lung cancer cells via mitogen-aetivated protein kinase kinase kinasc 1 activation[J]. Mol Cancer Ther, 2007,6: 1440-1449. 被引量:1

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