摘要
目的:观察中西医联合治疗儿童急性感染性鼻-鼻窦炎的减毒增效作用。方法:将急性鼻-鼻窦炎患儿106例随机分为观察组51例,对照组55例。对照组服用阿莫西林克拉维酸钾7∶1制剂或克拉霉素,分早晚2次口服;观察组在对照组治疗的基础上加用自拟方治疗,每日1剂;两组均连服2周。观察患儿治疗1周、2周时病情变化情况,并评价疗效。结果:治疗1周后总有效率观察组为58.8%(30/51),对照组为56.4%(31/55),两组比较差异无统计学意义(P>0.05);治疗2周后总有效率观察组为82.4%(42/51),对照组为76.4%(42/55),两组总有效率比较差异无统计学意义(P>0.05);观察组治疗后血清白细胞介素4(interleukin-4,IL-4)水平比治疗前下调,差异有统计学意义(P<0.05),而血清肿瘤坏死因子α(tumor necrosis factorα,TNF-α)较治疗前增高,差异有统计学意义(P<0.05)。两组不良反应发生率比较,观察组低于对照组,差异有统计学意义(P<0.05)。结论:解表清里法联合西药治疗儿童急性感染性鼻-鼻窦炎疗效优于单纯西药治疗,且不良反应发生率低,其疗效可能与免疫调节有关。
Objective:To observe the attenuated and synergetic effects of integrative medicine in the treatment for acute pediatric rhinitis-nasosinusitis.Methods:All 106 children were randomized into 51 cases of the observation group and 55 cases of the control group.The control group were given amoxicillin clavulanate potassium preparation(7∶1)or clarithromycin,twice each day,in the morning and evening;the treatment group were treated with selfmade prescriptions based on Western medicine,one dose each day;both groups took the drug for two weeks consecutively.To observe the disease changes one week and two weeks after treating,and assess clinical effects.Results:Total effective rate of the observation group one week after treating was 58.8%(30/51),higher than 56.4%(31/55)of the control group,and the difference had no statistical meaning in total effective rates between both groups(P>0.05);two weeks after treating,total effective rate of the observation group was 82.4%(42/51),higher than 76.4%(42/55)of the control group,and the difference had no statistical meaning(P>0.05),the levels of IL-4 reduced in the observation group after treating compared with before treating,and the difference showed statistical meaning(P<0.05),while the levels of TNF-α lifted notably,and the difference showed statistical meaning(P<0.05).The observation group was lower than the control group in the incidence of adverse reaction,and the difference showed statistical meaning(P<0.05).Conclusion:Exterior-relieving interior-clearing therapeutic method combined with Western medicine is effective in the treatment for acute pediatric rhinitis-nasosinusitis with low incidence of adverse reaction,and its effects might be related to immunoregulation.
作者
于凤英
李长英
王鹏善
薛世萍
YU Fengying;LI Changying;WANG Pengshan;XUE Shiping(Gaotai County TCM Hospital,Gaotai 734300,China;Gansu Provincial Academy of Chinese Medicine)
出处
《西部中医药》
2020年第1期119-121,共3页
Western Journal of Traditional Chinese Medicine
关键词
鼻窦炎
儿童
解表清里法
中西医结合
nasosinusitis
children
clinical effects
exterior-relieving interior-clearing method
integrative medicine
