摘要
细胞焦亡是一种促炎症性的细胞死亡方式,它是依赖于半胱氨酸天冬氨酸酶-1(caspase-1)的经典路径和依赖于半胱氨酸天冬氨酸酶-4/5/11(caspase-4/5/11)的非经典路径的激活所引起的炎性级联放大反应,最终促使细胞死亡并释放炎症因子白细胞介素-1β/18(IL-1β/18),焦亡的直接执行蛋白是GSDMD-N端结构域。银屑病的发病机制与caspase-1、IL-18、IL-1β、炎症小体(NLRP3、AIM2)有一定的相关性,本文综述细胞焦亡在银屑病发病中作用的研究进展,为银屑病的防治提供新的思路。
Pyroptosis is a pro-inflammatory form of cell death.It is an inflammatory cascade amplification reaction caused by activation of the caspase-1 dependent canonical pathway and caspase-4/5/11 dependent noncanonical pathway,which eventually leads to cell death and the release of inflammatory cytokine-1β/18(IL-1β/18).The direct executor of pyroptosis is N domain of the GSDMD.The pathogenesis of psoriasis is correlated with caspase-1,IL-18,IL-1β,and inflammasomes(NLRP3,AIM2).The advances of research on the role of pyroptosis in psoriasis were reviewed in this article,which might provide new thoughts for the prevention and treatment of psoriasis.
作者
王丽雅
朱晓芳
WANG Liya;ZHU Xiaofang(Medical School of Yangzhou University,Yangzhou 225001,China;Department of Dermatology,Clinical Medical School of Yangzhou University,Yangzhou 225001,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2020年第2期220-223,共4页
The Chinese Journal of Dermatovenereology
基金
扬州市科技计划项目-社会发展(YZ2018065)。
