摘要
目的 对精神分裂症患者的体内血清蛋白因子浓度进行了研究并和对照组结果进行比较,同时进一步分析了血清蛋白(VEGF)浓度和患者认知能力间的关联性。方法 选择2011-2016年在本院确诊的首发未服药精神分裂症患者90例作为研究组,另选同期在本院进行体检的健康人员88名作为对照组,采用酶联免疫吸技术(ELISA)对VEGF蛋白因子浓度进行测试。通过应用测试精神分裂症的成套认知功能检测版(MCCB)对上述人员的认知功能进行评价。结果 研究组患者的VEGF浓度明显比对照组更高(P<0.01),并且研究组的MCCB测试TMT得分也比对照组高(P<0.01),BACS SC、HVLT-R、WMS-ⅢSS、NAB、BVMT-R、CF评分低于对照组(P<0.01),同时发现研究组患者的血清蛋白浓度和BACS SC评分结果表现为负相关(P<0.01)。结论 研究组患者和常规对照人员的血清蛋白因子浓度不存在统计学差异性,同时测试结果进一步显示研究组患者在个人认知功能方面出现的障碍和VEGF浓度可能具有一定的联系。
Objective To investigate the concentration of vascular endothelial growth factor(VEGF)in the patients with schizophrenia,and compare with the healthy control.Further analysis of the association between serum protein(VEGF)concentration and patient cognitive ability was conducted.Methods Ninety drugnegative patients with schizophrenia onset for the first time,those diagnosed in the hospital during 2011 and 2016,were enrolled in the study as the study group.Another 88 people received physical examination in our hospital was selected as the healthy controls.The serum level of VEGF was detected with sandwich enzyme linked immunosorbent assay(ELISA),and the MCCB was used to evaluate cognitive ability in patients and controls.Results The serum levels of VEGF in patients were significantly higher than that in the controls(P<0.01).The scores of TMT in MCCB testing in patients were highercompared to controls.The scores of BACS SC,HVLT-R,WMS-III SS,NAB,BVMT-R,and CF in patients were lower than the controls.Meanwhile,a negative correlation was found between the serum protein concentration and the BACS SC score in patients(P<0.01).Conclusions There is no significant difference in serum protein factor concentration between the patients and the control,and further results indicates a relationship between the cognitive impairment and the serum levels of VEGF inpatients.
作者
徐子峰
张前升
孙珊
平亮亮
XU Zi-feng(Xianyue hospital of Xiamen,Xiamen,Fujian,361000,China)
出处
《齐齐哈尔医学院学报》
2019年第24期3085-3087,共3页
Journal of Qiqihar Medical University
关键词
精神分裂症
血清蛋白因子
认知功能
Schizophrenia
Serum protein factors
Cognitive function
