摘要
目的观察抑郁症对冠心病患者血管紧张素及血脂的影响。方法选择2018年7-12月于贵州省人民医院心内科住院治疗的冠心病患者126例作为冠心病组,根据抑郁评分将冠心病患者分为抑郁组(58例)及非抑郁组(68例),另选取同期于门诊健康体检者64例作为对照组。比较各组受试者血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血管紧张素(Ang)Ⅰ、AngⅡ、醛固酮(ALD)水平、汉密尔顿抑郁量表(HAMD)评分及汉密尔顿焦虑量表(HAMA)评分,分析冠心病患者合并抑郁症的相关危险因素。结果冠心病组患者TG、TC及LDL-C水平均高于对照组(P <0. 05);抑郁组患者TG、LDL-C及TC水平均高于非抑郁组(P <0. 05)。抑郁组及非抑郁组患者AngⅠ水平、AngⅡ水平、ALD水平、HAMA评分及HAMD评分均高于对照组,抑郁组患者AngⅠ水平、AngⅡ水平、HAMA评分及HAMD评分均高于非抑郁组(P <0. 05)。抑郁组与非抑郁组患者ALD水平比较差异无统计学意义(P> 0. 05)。Pearson相关分析结果显示,冠心病患者的抑郁程度与ALD、AngⅠ及AngⅡ水平呈正相关(P <0. 05)。二元Logistic回归分析结果显示,ALD、AngⅠ、AngⅡ水平为冠心病患者合并抑郁症的独立危险因素。结论冠心病患者合并抑郁症与ALD及Ang水平呈正相关,Ang及ALD水平均为冠心病患者合并抑郁症的独立危险因素。
Objective To analyze the effects of depression on angiotensin and blood lipids in patients with coronary heart disease. Methods 126 patients with coronary heart disease who were hospitalized in the Department of Cardiology,Guizhou Provincial People’s Hospital from July to December 2018 were selected as the coronary heart disease group. According to the depression score,patients with coronary heart disease were divided into depression group(58 cases) and non-depression group(68 cases). Another 64 healthy people who had undergone outpatient health examination during the same period were selected as the control group. Compared serum total cholesterol(TC), triacylglycerol(TG), high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),angiotensin(Ang) Ⅰ,AngⅡ,aldosterone(ALD) levels,Hamilton Depression Scale(HAMD) score,and Hamilton Anxiety Scale(HAMA) score,analyzed the related risk factors of depression in patients with coronary heart disease. Results The levels of TG,TC and LDL-C in patients with coronary heart disease were higher than those in the control group(P < 0. 05);The levels of TG,LDL-C and TC in patients in depression group were higher than those in non-depression group(P < 0. 05). The AngⅠ level,AngⅡ level,ALD level,HAMA score and HAMD score of patients in depression group and non-depression group were higher than those in the control group. The AngⅠ level,AngⅡ level,HAMA score and HAMD score of patients in depression group were higher than those in non-depression group(P < 0. 05). There was no significant difference in the ALD level between patients with depression and non-depression(P > 0. 05). Pearson correlation analysis showed that depression in patients with coronary heart disease was positively correlated with ALD,AngⅠ,and Ang Ⅱ levels(P < 0. 05). The results of binary logistic regression analysis showed that ALD,Ang Ⅰ,and Ang Ⅱ levels were independent risk factors for depression in patients with coronary heart disease.Conclusion Coronary heart dis
作者
刘兴会
张长海
刘晓桥
张萍
谭洪文
LIU Xinghui;ZHAGN Changhai;LIU Xiaoqiao(Department of Cardiology,Guizhou Provincial People's Hospital,Guizhou Province,Guiyang 550002,China)
出处
《临床合理用药杂志》
2020年第2期9-11,共3页
Chinese Journal of Clinical Rational Drug Use
基金
贵州省科技厅基金支助项目(No:黔科合LH字[2016]7180)。
关键词
抑郁
冠心病
血管紧张素
血脂
Depression
Coronary heart disease
Angiotensin
Blood lipids
