摘要
矽肺是在生产过程中长期吸入较高浓度的粉尘引起的以肺部纤维化为主的职业性疾病,是最为常见的职业病。矽肺的发病机制长期以来国内外都在研究,为探究矽肺的发病机制,研究治疗方法,建立动物模型至关重要。该文通过对矽肺动物模型的相对全面的介绍,为矽肺的临床研究应用提供更多的选择。
Silicosis is an occupational disease mainly caused by pulmonary fibrosis caused by long-term inhalation of high concentrations of dust during the production process. It is the most common occupational disease. The pathogenesis of silicosis has been studied at home and abroad for a long time. It is essential to explore the pathogenesis of silicosis,study treatment methods,and establish animal models. This article provides a more comprehensive selection of clinical research applications for silicosis through a relatively comprehensive introduction to silicosis animal models.
作者
张丹参
金姗
ZHANG Dan-shen;JIN Shan(Hebei University of Science and Technology,Shijiazhuang,050018,China)
出处
《神经药理学报》
2019年第6期21-25,共5页
Acta Neuropharmacologica
基金
河北省自然科学基金项目(No.H2016208058)
河北省高等学校科学技术研究项目(No.ZD2016009)。
关键词
矽肺
动物模型
二氧化硅
评价
silicosis
animal model
silica
evaluation
