摘要
癌细胞生长迅速及中心血供不足导致的缺氧是肿瘤微环境特性之一,在胰腺癌中尤为突出。越来越多的研究显示,缺氧与胰腺癌的血管新生、代谢重建、肿瘤增殖及早期浸润转移密切相关,并通过分泌多种活性因子介导肿瘤免疫逃避。此外,耐药作为胰腺癌治愈率低的关键因素,也与缺氧相关。缺氧与胰腺癌的发生发展密不可分,并依赖于缺氧诱导因子发挥作用。对缺氧微环境与胰腺癌的关系进行了总结,并探讨相关信号通路激活与分子机制,以期为胰腺癌缺氧微环境靶向治疗提供线索。
Hypoxia caused by rapid growth of cancer cells and insufficient central blood supply is one of the characteristics of tumor microenvironment,especially in pancreatic cancer.An increasing number of studies have shown that hypoxia is closely associated with angiogenesis,metabolic reprogramming,tumor proliferation,and early invasion and metastasis of pancreatic cancer and can mediate tumor immune evasion by secreting a variety of active factors.In addition,as a key factor for the low cure rate of pancreatic cancer,drug resistance is also associated with hypoxia.Hypoxia is closely associated with the development and progression of pancreatic cancer and depends on hypoxia-inducible factor.This article summarizes the association between hypoxic microenvironment and pancreatic cancer and discusses the activation of related signaling pathways and molecular mechanisms,in order to provide clues for targeted therapy for hopoxic microenvironment in pancreatic cancer.
作者
张雨
江建新
ZHANG Yu;JIANG Jianxin(Department of Hepatobiliary Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第3期708-712,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金(8187101814)。
关键词
胰腺肿瘤
缺氧
肿瘤微环境
pancreatic neoplasms
hypoxia
tumor microenvironment
