摘要
目的探讨膈下逐瘀汤加减治疗对气滞血瘀型肝癌患者的有效性及肝功能指标的影响。方法选取2014年5月至2019年5月本院收治的气滞血瘀型肝癌患者100例,随机分为两组,各50例。对照组给予FOLFOX4全身化疗,研究组给予膈下逐瘀汤加减治疗。对比两组临床总有效率,ALT、TBIL、HA、LN以及PCⅢ水平进行分析。结果研究组治疗总有效率92.0%(46/50),高于对照组64.0%(32/50),差异有统计学意义(P<0.05);治疗后,研究组AFP、ALT、TBIL水平分别为(401.5±102.1)μg/L、(41.1±13.7)U/L、(9.1±2.2)μmol/L,均低于对照组(678.7±129.6)μg/L、(83.2±21.9)U/L、(19.4±5.3)μmol/L,差异均有统计学意义(均P<0.05);治疗后,研究组HA、LN、PCⅢ水平分别为(168.2±12.7)μg/L、(158.7±14.8)μg/L、(11.3±3.7)μg/L,均低于对照组(301.7±14.5)μg/L、(351.2±29.9)μg/L、(22.5±6.2)μg/L,差异均有统计学意义(均P<0.05)。结论气滞血瘀型肝癌患者采用膈下逐瘀汤加减治疗效果比较可观,可有效促进患者肝功能的改善,降低肝脏纤维化症状,临床可推广使用。
Objective To investigate the effect of Gexia Zhuyu Decoction for patients with qi stagnation and blood stasis liver cancer and its influence on liver function.Methods A total of 100 patients with qi stagnation and blood stasis liver cancer treated at our hospital from May,2014 to May,2019 were randomly divided into a control group and a study group,with 50 patients in each group.The control group was treated with given FOLFOX4 systemic chemotherapy,and the study group with Gexia Zhuyu Decoction.The total clinical effective rates and levels of ALT,TBIL,HA,LN,and PCⅢwere compared between these two groups.Results The total effective rate was higher in the study group than in the control group[92.0%(46/50)vs.64.0%(32/50);P<0.05].After the treatment,the levels of AFP,ALT,TBIL HA,LN,and PCⅢwere lower in the observation group than in the control group[(401.5±102.1)μg/L vs.(678.7±129.6)μg/L,(41.1±13.7)U/L vs.(83.2±21.9)U/L,(9.1±2.2)μmol/L vs.(19.4±5.3)μmol/L,(168.2±12.7)μg/L vs.(301.7±14.5)μg/L,(158.7±14.8)μg/L vs.(351.2±29.9)μg/L,and(11.3±3.7)μmol/L vs.(22.5±6.2)μmol/L;all P<0.05].Conclusion Gexia Zhuyu Decoction for patients with qi stagnation and blood stasis liver cancer is effective,and can effectively improve their liver function and reduce their symptoms of liver fibrosis,so it is worth being clinically generalized.
作者
荆进红
强春倩
Jing Jinhong;Qiang Chunqian(Yantai Qishan Hospital,Yantai 264000,China)
出处
《国际医药卫生导报》
2020年第4期539-542,共4页
International Medicine and Health Guidance News
关键词
膈下逐瘀汤
加减治疗
气滞血瘀型
肝癌
肝功能指标
Gexia Zhuyu Decoction
Plus or minus treatment
Qi stagnation and blood stasis type
Liver cancer
Liver function indicators
