摘要
Dickkopfs是Wnt/β-catenin信号通路的抑制因子,具有抑制肿瘤生长的作用。Dickkopfs分泌蛋白可用作临床诊断和治疗的靶点,因此,有关Dickkopfs分泌蛋白精准有效调控肿瘤细胞机制及靶向抑制剂的研究,是癌症研究中重要的研究对象之一。目前的研究对Dickkopfs蛋白家族缺乏系统性归纳,因此对Dickkopfs在肿瘤细胞中的调控机制进行分析。结果发现:DKK1、DKK2、DKK4主要通过引起蛋白酶体β-catenin降解、诱导细胞凋亡和阻止细胞增殖来抑制Wnt/β-catenin通路;DKK3是通过对β-catenin的下游信号通路因子进行负调控的详细机制。阐述了Dickkopfs分泌蛋白在临床诊断、治疗及预后的应用,并对其可能存在抑制肿瘤血管生成机制进行了展望。
Dickkopfs is an inhibitor of Wnt/β-catenin signaling pathway and play a role in inhibiting tumor growth.Dickkopfs secreted protein can be used as a target for clinical diagnosis and treatment.Therefore,the research on the precise and effective regulation of tumor cell mechanism and targeted inhibitors by Dickkopfs secreted protein is one of the important research objects in cancer research.The current study lacks a systematic induction of the Dickkopfs protein family.Therefore,the regulatory mechanism of Dickkopfs in tumor cells was analyzed.The results show that:DKK1,DKK2 and DKK4 inhibit Wnt/β-catenin pathway mainly by causing degradation of proteasomeβ-catenin,inducing apoptosis and preventing cell proliferation.DKK3 negatively regulates downstream signaling pathway ofβ-catenin.This paper expounds the application of Dickkopfs secreted protein in clinical diagnosis,treatment and prognosis,and expects its possible mechanism of inhibiting tumor angiogenesis.
作者
陈曦
孙延芳
WINSTON Nxumalo
CHEN Xi;SUN Yanfang;WINSTON Nxumalo(College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018,China;Department of Chemistry,School of Physical and Mineral Sciences,University of Limpopo,Sovenga 0727,South Africa)
出处
《浙江理工大学学报（自然科学版）》
2020年第2期253-261,共9页
Journal of Zhejiang Sci-Tech University(Natural Sciences)
基金
国家自然科学基金项目(81602648)
国家自然科学基金国际(地区)合作与交流项目(81911530168)。
