摘要
脑小血管病(cerebral small vessel disease,CSVD)在影像学上主要表现为腔隙性梗死或腔隙、白质高信号(white matter hyperintensities,WMHs)、血管周围间隙扩大(enlarged perivascular space,EPVS)、脑微出血及脑萎缩等。研究表明,额叶、枕叶、侧脑室旁和基底节区WMHs是头晕/眩晕的重要原因,头晕/眩晕症状发作频率随WMHs的加重而增高。此外,皮质下梗死、EPVS、脑萎缩等也与头晕/眩晕紧密关联。神经传导通路损害、炎症浸润性损伤、前庭退行性病变、精神心理障碍以及大血管/小血管病相关血流灌注不足等可能是CSVD促发头晕/眩晕的重要途径。早期识别和诊断CSVD相关性头晕/眩晕,有助于进行针对性预防和治疗。
Cerebral small vessel disease(CSVD)is mainly manifested as lacunar infarction or lacunar space,white matter hyperintensities(WMHs),enlarged perivascular space(EPVS),cerebral microbleeds,and brain atrophy in imaging examination.Studies have shown that WMHs in the frontal lobe,occipital lobe,lateral ventricle,and basal ganglia are the important causes of dizziness/vertigo.The frequency of dizziness/vertigo symptoms increases with the worsening of WMHs.In addition,subcortical infarction,EPVS,and brain atrophy are also closely associated with dizziness/vertigo.Nerve conduction pathway damage,inflammatory infiltrating damage,vestibular degenerative lesions,mental and psychological disorders,and insufficient perfusion of blood vessels associated with large/small vessel disease may be the important ways for triggering dizziness/vertigo in CSDV.Early identification and diagnosis of CSVD-related dizziness/vertigo may contribute to the targeted prevention and treatment.
作者
王伟涛
张道培
张怀亮
Wang Weitao;Zhang Daopei;Zhang Huailiang(Department of Neurology,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)
出处
《国际脑血管病杂志》
2019年第12期929-933,共5页
International Journal of Cerebrovascular Diseases
基金
吴阶平医学基金会(320.6750.18326)
全国名老中医药专家传承工作室建设项目(国中医药人教函[2018]134号)。
关键词
脑小血管疾病
眩晕
头晕
Cerebral small vessel disease
Vertigo
Dizziness
