摘要
目的 探讨尿激酶联合丹参酮ⅡA磺酸钠治疗老年急性心肌梗死的临床疗效及对血清Fractalkine、人生长分化因子-15(GDF-15)水平的影响。方法 选取邯郸明仁医院2016年1月至2018年12月收治的老年急性心肌梗死患者106例,随机分为观察组和对照组,各53例。两组患者均在常规治疗基础上予注射用尿激酶治疗,观察组患者加用丹参酮ⅡA磺酸钠注射液治疗。结果 观察组总有效率为90.57%,明显高于对照组的75.47%(P<0.05);与治疗前比较,两组患者治疗后的左室射血分数(LVEF)均显著升高,左室收缩末内径(LVESd)、左室舒张末内径(LVEDd)、血清Fractalkine、GDF-15水平均显著降低(P<0.05);观察组与对照组不良反应发生率相当(16.98%比11.32%,P>0.05)。结论 尿激酶联合丹参酮ⅡA磺酸钠治疗老年急性心肌梗死,可改善患者的心功能指标,降低血清Fractalkine和GDF-15水平。
Objective To study the effect of urokinase combined with sodium tanshinoneⅡA sulfonate in the treatment of elderly patients with acute myocardial infarction and its influence on serum Fractalkine and human growth differentiation factor(GDF-15)levels.Methods A total of 106 elderly patients with acute myocardial infarction admitted from January 2016 to December 2018 in the hospital were selected and randomly divided into the observation group and control group,53 cases in each group.The control group was treated with urokinase on the basis of routine treatment,while the observation group was treated with tanshinoneⅡA sulfonate on the basis of the control group.Results The total effective rate in the observation group was 90.57%,which was significantly higher than75.47% in the control group(P<0.05).Compared with before treatment,the left ventricular ejection fraction(LVEF)of the two groups were significantly increased;the levels of left ventricular end-systolic diameter(LVESd),left ventricular end-diastolic diameter(LVEDd),serum Fractionale,and GDF-15 were significantly decreased(P<0.05).The incidence of adverse reactions was similar between the two groups(16.98% vs.11.32%,P>0.05).Conclusion Urokinase combined with sodium tanshinoneⅡAsulfonate is effective in the treatment of elderly patients with acute myocardial infarction.It can improve the cardiac function of patients and reduce the levels of serum Fractalkine and GDF-15.
作者
秦浩玲
马会
梁书丽
马红莉
QIN Haoling;MA Hui;LIANG Shuli;MA Hongli(Handan Mingren Hospital,Handan,Hebei,China 056000;Wuan First People's Hospital,Handan,Hebei,China 056300)
出处
《中国药业》
CAS
2020年第6期145-147,共3页
China Pharmaceuticals
基金
河北省中医药管理局科研计划项目[2019396]。
关键词
急性心肌梗死
老年
尿激酶
丹参酮ⅡA磺酸钠
心功能指标
血清学指标
acute myocardial infarction
elderly
urokinase
sodium tanshinoneⅡA sulfonate
cardiac function indicators
serological indicators
