摘要
急性呼吸窘迫综合征(ARDS)是一种高发病率、高病死率的异质性临床综合征。弥漫性肺泡损伤(DAD)是ARDS典型病理特征,但肺尸检和肺活检发现大约只有一半符合柏林ARDS定义的患者存在DAD。与非DAD-ARDS患者相比,DAD-ARDS患者死亡率显著增高,二者可能存在不同的细胞和分子机制。本文旨在探讨ARDS与DAD的关系及其临床意义,以期为临床上更好地诊治ARDS提供新的思路。
Acute respiratory distress syndrome(ARDS)is a heterogeneous clinical syndrome with high morbidity and mortality.Diffuse alveolar damage(DAD)is the typical pathological feature of ARDS,but pulmonary autopsies and lung biopsies have found that only about half of patients meeting the Berlin definition of ARDS have DAD.Compared with non-DAD-ARDS patients,the mortality rate of DAD-ARDS patients is significantly higher,there may be different cellular and molecular mechanisms.This article aims to explore the relationship between ARDS and DAD and its clinical significance,in order to provide new ideas for the better diagnosis and treatment of ARDS.
作者
解冰洁
李爱民
Xie Bingjie;Li Aimin(The First School of Clinical Medicine,Shanxi Medical University,Taiyuan 030001,China;Department of Respiratory and Critical Care Medicine,the First Hospital,Shanxi Medical University,Taiyuan 030001,China)
出处
《国际呼吸杂志》
2020年第3期225-228,共4页
International Journal of Respiration
关键词
呼吸窘迫综合征
成人
弥漫性肺泡损伤
诊断
Respiratory distress syndrome
adult
Diffuse alveolar damage
Diagnosis
