摘要
通过将自制铅笔芯电极在0.1 mol/L KClO 4和Na2CO3混合溶液中进行电化学活化,有效提高了铅笔芯电极的电催化性能。所制得的活化铅笔芯电极对扑热息痛的电化学氧化呈现出良好的催化效应,可用于扑热息痛的电化学传感。扫描电镜表征显示,该活化电极表面呈多孔疏松结构,拥有较大的比表面积,有利于增强扑热息痛在电极表面的富集,从而提高传感器的灵敏度。此外,还借助电化学技术对扑热息痛在活化铅笔芯电极上的电化学传感机理进行了探讨。研究发现,扑热息痛在传感器表面的电化学氧化是一个两电子两质子的过程。在最佳的检测条件下,扑热息痛的氧化峰电流与其浓度分别在3.0×10^-6~1.0×10^-5 mol/L及1.0×10^-5~1.0×10^-4 mol/L浓度范围内呈良好的线性关系,检出限低至9.0×10^-7 mol/L。将该传感器用于药片中扑热息痛含量的检测,平均回收率为100.6%。
In this work,the surface performance of pencil graphite electrode has been improved effectively just through electrochemical activating in the solution containing 0.1 mol/L KClO 4 and Na 2 CO 3.The electrochemical activated pencil graphite electrode shows good electrocatalytic ability to the oxidation of paracetamol and can be applied in its electrochemical sensing.The surface structure of electrochemical activated pencil graphite electrode has been characterized through scanning electron microscope and the result show that it has a three-dimensional network structure with a larger specific surface area,which is conducive to increasing the concentration of paracetamol on the electrode surface and further improving the sensitivity of the sensor.Furthermore,the electrochemical reaction mechanism of paracetamol on the electrochemical activated pencil graphite electrode has been discussed through electrochemical techniques and the results show that it is a process involving two electrons and two protons.Under the optimal detection conditions,the oxidation peak current of paracetamol has a good linear relationship with its concentration in the range of 3.0×10^-6-1.0×10^-5 mol/L and 1.0×10^-5-1.0×10^-4 mol/L.The detection limit was measured to be 9.0×10^-7 mol/L through experiment.In addition,the sensor has been applied to the determination of paracetamol in tablets with satisfactory results.
作者
郑霄
陈苏靖
李芳芳
邓娟
郑冬云
ZHENG Xiao;CHEN Sujing;LI Fangfang;DENG Juan;ZHENG Dongyun(College of Biomedical Engineering,South-Central University for Nationalities,Wuhan 430074;Key Laboratory of Brain Cognitive Science(South-Central University for Nationalities),State Ethnic Affairs Commission,Wuhan 430074;Hubei Key Laboratory of Medical Information Analysis&Tumor Diagnosis and Treatment,Wuhan 430074)
出处
《分析科学学报》
CAS
CSCD
北大核心
2020年第1期13-18,共6页
Journal of Analytical Science
基金
国家自然科学基金(No.61501526,21804146)
湖北省自然科学基金(No.2018CFC836)
武汉市晨光计划(No.2017050304010322)
中央高校基本科研业务费专项资金(No.CZY14017,CZY16007,CZQ16011,CZZ17007,CZY18028,CZQ18014)
关键词
铅笔芯电极
电化学活化
扑热息痛
电化学传感
Pencil graphite electrode
Electrochemically activated
Paracetamol
Electrochemical sensing
