摘要
目的:评价温和灸配合隔盐灸改善乳腺癌化疗所致胃肠道反应的疗效,胃蛋白酶原及部分作用机制。方法:将48例患者随机分为观察组和对照组,每组24例。对照组使用注射用盐酸托烷司琼(5 mg),静脉滴注,每日1次,共治疗3d;观察组在对照组治疗基础上配合使用温和灸足三里、中脘、关元、气海及隔盐灸神阙,每天1次,每次15 min,共治疗7 d。分别于治疗前及化疗第7天监测两组患者血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、PGⅠ与PGⅡ比值(PGR)和胃泌素-17(G-17)水平。分别于治疗前与化疗第3、5、7天,比较两组患者胃肠道反应程度(恶心、呕吐、便秘、腹泻症状评分)。结果:化疗第7天,观察组血清PGⅠ、PGⅡ、G-17水平低于对照组(P<0.05),PGR与对照组比较差异无统计学意义(P>0.05)。化疗期间观察组恶心、呕吐、便秘总体评分较对照组明显降低(P<0.05)。结论:温和灸配合隔盐灸可以有效改善乳腺癌化疗引起的恶心、呕吐、便秘症状,其机制可能与下调血清PGⅠ、PGⅡ及G-17水平有关。
Objective To evaluate the clinical efficacy and partial action mechanism of mild moxibustion combined with salt-separated moxibustion for gastrointestinal discomfort caused by chemotherapy for breast cancer. Methods A total of 48 patients were randomly divided into an observation group and a control group, 24 cases in each group. The patients in the control group were treated with intravenous infusion of tropisetron hydrochloride(5 mg), once a day for three days;the patients in the observation group were additionally treated with mild moxibustion at Zusanli(ST 36), Zhongwan(CV 12), Guanyuan(CV 4), Qihai(CV 6) and salt-separated moxibustion at Shenque(CV 8), 15 min per treatment, once a day for 7 days. Before treatment and on the 7 th day of chemotherapy, the levels of pepsinogenⅠ(PGⅠ), pepsinogenⅡ(PGⅡ), the ratio of PGⅠto PGⅡ(PGR) and gastrin 17(G-17) in serum were measured. Before treatment and on the 3 rd, 5 th, 7 th day of chemotherapy, the gastrointestinal reactions(nausea, vomiting, constipation, diarrhea) were compared between the two groups. Results On the 7 th day of chemotherapy, the serum levels of PGⅠ, PGⅡand G-17 in the observation group were lower than those in the control group(P<0.05), and the difference in the level of PGR in serum between the observation group and the control group was not statistically significant(P>0.05). The total scores of nausea, vomiting and constipation during chemotherapy in the observation group were significantly lower than those in the control group(all P<0.05). Conclusion The mild moxibustion combined with salt-separated moxibustion could effectively improve the symptoms of nausea, vomiting and constipation caused by chemotherapy in patients with breast cancer, and its mechanism may be related to the down-regulation of the levels of PGⅠ, PGⅡ and G-17 in serum.
作者
郭琪
姚昶
郭宇飞
汪梅
GUO Qi;YAO Chang;GUO Yu-fei;WANG Mei(A ffiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu Province,China;Department of Breast,Second Affiliated Hospital of Henan University of TCM,Henan Hospital of TCM)
出处
《中国针灸》
CAS
CSCD
北大核心
2020年第1期8-12,共5页
Chinese Acupuncture & Moxibustion
基金
江苏省中医院高峰学术人才培养项目：k2018yrc11
关键词
乳腺癌化疗
温和灸
隔盐灸
胃肠道反应
胃蛋白酶原
胃泌素
breast cancer chemotherapy
mild moxibustion
salt-separated moxibustion
gastrointestinal discomfort
pepsinogen
gastrin
