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酰胺质子转移成像在肿瘤影像学中的应用进展 被引量:4

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摘要 酰胺质子转移(amide proton transfer,APT)成像,是一种选择性抑制组织信号的新型磁共振分子成像技术,由化学交换饱和转移(chemical exchange saturation transfer,CEST)技术衍生而来,它能够从分子水平反映组织细胞内游离蛋白质的浓度特性。蛋白质不仅是细胞结构的组成部分,而且是细胞功能的执行者,因而评估蛋白质浓度变化有助于了解细胞的活动状态。目前,APT成像已在多种肿瘤的成像方面显示出良好的发展前景,尤其在脑肿瘤的应用中展现出较大优势。本文旨在简述APT成像的基本原理,并介绍其在肿瘤影像学方面的应用进展。
作者 刘娜
出处 《实用医学影像杂志》 2020年第1期50-52,共3页 Journal of Practical Medical Imaging
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