摘要
2-(2-苯乙基)色酮类化合物仅分布在少数植物中,具有神经保护、抗菌和抗炎等多种生物活性,是沉香的特征性成分和主要活性成分,具有广阔的药用前景和应用价值。笔者对2-(2-苯乙基)色酮类化合物的神经保护活性、抗肿瘤细胞毒活性、抗菌活性和抗炎活性等生物活性、构效关系及生物合成途径的研究现状进行综述和展望,以期为筛选药用2-(2-苯乙基)色酮类化合物和对其生物合成途径的解析提供参考,并指出了目前生物合成研究中存在的问题。
2-(2-Phenylethyl)chromones are only distributed in a few plant species and have many bioactivities such as neuropro tection,antibacterial and anti-inflammatory effects.They are the characteristic and main active components of agarwood.They are expected to have broad medicinal application value.In this paper,the research progress of the biological activities such as neuroprotective activity,anti-tumor cytotoxic activity,antibacterial activity and anti-inflammatory activity,as well as the structure-activity relationship and biosynthetic pathway of 2-(2-phenethyl)chromone compounds were reviewed and prospected.It provides a reference for screening the pharmaceutical 2-(2-phenethyl)chromone compounds and analyzing their biosynthetic pathways.Some problems in the current biosynthesis researches are also pointed out here.
作者
肖梦君
高志晖
魏建和
XIAO Meng-jun;GAO Zhi-hui;WEI Jian-he(Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education&National Engineering Laboratory for Breeding of Endangered Medicinal Materials,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China;Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine&Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization,Hainan Branch of the Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Haikou 570311,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2019年第23期1909-1918,共10页
Chinese Pharmaceutical Journal
基金
中国医学科学院医学与健康科技创新工程资助(重大协同创新项目)(2016-I2M-2-003)
国家重点研发计划项目资助(2018YFC1706400)
中组部“万人计划”资助(99950534)
国家中药材产业技术体系资助(CARS-21)。
