摘要
钙敏感受体(calcium sensing receptor,CaSR)是体内广泛表达的一种跨膜受体,主要功能是通过调节甲状旁腺激素的分泌维持机体的钙稳态。此外,钙敏感受体还参与多种生理病理过程的精细调控。越来越多的研究表明,钙敏感受体与肿瘤的发生发展密切相关。由于钙敏感受体的功能多样性和组织特异性,在不同的肿瘤类型中,钙敏感受体表现出促癌和抑癌两种截然相反的作用:在前列腺癌、肾癌中表现为促癌作用;在结肠癌、成神经细胞瘤、甲状旁腺癌中表现为抑癌作用。对钙敏感受体在肿瘤中的作用机制研究,有利于以钙敏感受体为靶点的抗肿瘤药物筛选和研发以及肿瘤的精准治疗。基于此,该文总结了钙敏感受体在不同肿瘤中的作用及其机制,有望为相关研究提供理论借鉴和参考。
As a widely-expressed transmembrane receptor,calcium sensing receptor(CaSR)plays an important role in maintaining body calcium homeostasis by regulating parathyroid hormone secretion.In addition,CaSR is implicated in various physiological and pathological processes.Increasing evidences indicate that CaSR is closely related to tumor progression.Due to the functional diversity and tissue specificity,CaSR may function as either tumor promoter or tumor suppressor in different types of tumors.CaSR acts as a tumor promoter in prostate cancer and renal cell carcinoma.While in colon cancer,neuroblastoma and parathyroid carcinoma,CaSR is a tumor suppressor.Studies on the role of CaSR in different tumors are beneficial to research and development of new anti-tumor drugs,as well as tumor therapy targeting CaSR.Herein,we summarized the function and underlying mechanism of CaSR in different types of tumors,aiming to provide theoretical basis for future research.
作者
吴仕勇
马淑敏
易平
刘剑峰
WU Shiyong;MA Shumin;YI Ping;LIU Jianfeng(College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第10期2012-2018,共7页
Chinese Journal of Cell Biology
关键词
钙敏感受体
肿瘤
作用机制
calcium sensing receptor
tumor
function mechanism
