摘要
目的:分析中度慢性牙周炎患者运用替硝唑片联合盐酸米诺环素软膏治疗的临床效果.方法:选择2017年7月-2019年7月笔者所在医院接诊的中度慢性牙周炎患者76例,按计算机随机分组法分为对照组和观察组.其中对照组38例,单纯给予盐酸米诺环素软膏治疗;观察组38例,给予替硝唑片联合盐酸米诺环素软膏治疗.分析两组患者临床疗效、牙周指标水平及不良反应发生率.结果:观察组治疗有效率94.74%,高于对照组的78.95%(字2=10.912,P=0.001);观察组GI、PLI、PD、PAL等牙周指标水平为(0.81±0.24)、(0.75±0.33)、(3.26±0.45)mm、(3.07±0.44)mm,低于对照组的(1.13±0.37)、(0.98±0.20)、(4.19±0.58)mm、(3.60±0.61)mm,差异均有统计学意义(t=4.473、3.674、7.810、4.344,P=0.001、0.001、0.001、0.001);观察组不良反应发生率10.52%,低于对照组的15.78%,但差异无统计学意义(字2=1.211,P=0.271).结论:中度慢性牙周炎患者运用替硝唑片联合盐酸米诺环素软膏治疗可以有效促进其病情好转,改善牙周指标水平,且不会导致用药副作用增加,在临床上具有借鉴与推广意义.
Objective:To analyze the clinical effect of Tinidazole Tablets combined with Minocycline Hydrochloride Ointment in the treatment of moderate chronic periodontitis.Method:A total of 76 patients with moderate chronic periodontitis who were admitted to our hospital from July 2017 to July 2019 were randomly divided into the control group and the observation group.Among them,38 cases in the control group were treated with Minocycline Hydrochloride Ointment alone,while 38 cases in the observation group were treated with Tinidazole Tablets combined with Minocycline Hydrochloride Ointment.The clinical efficacy,periodontal index and incidence of adverse reactions of the two groups were analyzed.Result:The effective rate of the observation group was 94.74%,which was higher than 78.95%of the control group(X^2=10.912,P=0.001).The periodontal index levels of GI,PLI,PD and PAL in the observation group were(0.81±0.24),(0.75±0.33),(3.26±0.45)mm,(3.07±0.44)mm,lower than(1.13±0.37),(0.98±0.20),(4.19±0.58)mm,(3.60±0.61)mm in the control group.The differences were statistically significant(t=4.473,3.674,7.810,4.344,P=0.001,0.001,0.001,0.001).The incidence of adverse reactions in the observation group was 10.52%,which was lower than 15.78%of the control group,but there was no significant difference(X^2=1.211,P=0.271).Conclusion:Tinidazole Tablets combined with Minocycline Hydrochloride Ointment can effectively improve the condition of patients with moderate chronic periodontitis,improve the level of periodontal indicators,and do not lead to increased side effects of medication.It has reference and popularization significance in clinical practice.
作者
邢俊
XING Jun(Nanping Maternal and Child Health Hospital,Nanping 353000,China)
出处
《中外医学研究》
2020年第2期40-42,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
替硝唑片
盐酸米诺环素软膏
中度慢性牙周炎
Tinidazole Tablets
Minocycline Hydrochloride Ointment
Moderate chronic periodontitis
