摘要
目的:探讨血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、可溶性血管内皮生长因子受体-1(soluble vascular endothelial growth factor receptor-1,sFLT1)和CD105水平变化对预测子宫内膜癌(endometrial carcinoma,EC)转移的价值。方法:选取本院妇科收治的97例EC患者进行研究,其中发生EC转移者42例(EC转移组),无转移者55例(EC无转移组),选取同期体检健康女性50例(对照组),采用酶联免疫吸附法(ELISA)检测所有受试者血清VEGF、sFLT1和CD105水平变化情况,进一步分析三者水平变化对预测EC转移的价值。结果:EC转移组、EC无转移组患者血清VEGF、VEGF/sFLT1、CD105水平高于对照组(P<0.05),EC转移组VEGF、VEGF/sFLT1水平高于EC无转移组(P<0.05),EC转移组、EC无转移组患者血清sFLT1水平低于对照组(P<0.05),且EC转移组血清sFLT1水平低于EC无转移组(P<0.05)。EC转移患者血清VEGF、sFLT1水平与肿瘤分期有关(P<0.05),与病理分级、浸润肌层深度无关(P>0.05),EC转移患者血清CD105水平与肿瘤分期、病理分级、浸润肌层深度均无关(P>0.05)。ROC曲线显示,VEGF的AUC为0.901,当临界值>503.26 pg/ml时,诊断敏感性为78.57%,特异性为94.00%;sFLT1的AUC为0.876,当临界值≤62.35 pg/ml时,诊断敏感性为73.81%,特异性为86.00%;CD105的AUC为0.692,当临界值>89.67 U/L时,诊断敏感性为64.30%,特异性为86.00%。VEGF是影响EC转移的独立危险因素(P<0.05),sFLT1是影响EC转移的独立保护因素(P<0.05)。结论:EC转移患者血清VEGF水平升高,sFLT1水平降低,VEGF/sFLT1比值升高,血清VEGF、sFLT1对EC转移患者具有较高敏感性和特异性,是EC转移的影响因素,可作为EC转移的潜在预测指标。
Objective:To investigate the value of serum vascular endothelial growth factor(VEGF),soluble vascular endothelial growth factor receptor-1(sFLT1)and CD105 levels in predicting the metastasis of endometrial carcinoma(EC).Methods:97 cases of EC patients admitted to the Department of Gynecology in our hospital were studied,including 42 cases with EC metastasis(EC metastasis group)and 55 cases without metastasis(EC non-metastasis group),and 50 healthy women(control group)in the same period were selected.Enzyme linked immunosorbent assay(ELISA)was used to detect the changes of serum VEGF,sFLT1 and CD105 levels in all subjects.The values of the three level changes to predict EC metastasis were analysed.Results:The levels of serum VEGF,VEGF/sFLT1 and CD105 in the EC metastasis group and the EC non-metastasis group were higher than those in the control group(P<0.05).The VEGF and VEGF/sFLT1 in the EC metastasis group were higher than those in the EC non-metastatic group(P<0.05),and the serum sFLT1 in EC metastasis group and EC non-metastasis group was lower than that in control group(P<0.05),and the serum sFLT1 level in the EC metastasis group was lower than EC non-metastasis group(P<0.05).The levels of serum VEGF and sFLT1 in patients with EC metastasis were related to the tumor staging(P<0.05).It was not related to pathological grading and depth of infiltrating muscularis(P>0.05).The expression of serum CD105 in patients with EC metastasis was not related to tumor staging,pathological grading and depth of infiltrating muscularis(P>0.05).The ROC curve showed that the AUC of VEGF was 0.901.When the critical value>503.26 pg/ml,the diagnostic sensitivity was 78.57%,and the specificity was 94.00%.The AUC of sFLT1 was 0.876.When the critical value≤62.35 pg/ml,the diagnostic sensitivity was 73.81%,and the specificity was 86.00%.The AUC of CD105 was 0.692.When the critical value>89.67 U/L,the diagnostic sensitivity was 64.30%,and the specificity was 86.00%.VEGF was an independent risk factor affecting EC metastasis(P<0.05),SF
作者
郭艳娟
何艳舫
赵楠楠
常慧
王兴
韩娜
Guo Yanjuan;He Yanfang;Zhao Nannan;Chang Hui;Wang Xing;Han Na(Department of Obstetrics and Gynecology,North China University of Science and Technology Affiliated Hospital,Hebei Tangshan 063000,China)
出处
《现代肿瘤医学》
CAS
2020年第5期784-788,共5页
Journal of Modern Oncology
基金
2018年度河北省医学科学研究课题计划(编号:20180016)
