摘要
目的分析多囊卵巢综合征(PCOS)患者孕期血清PTX-3、Adropin水平变化及其与临床特点和左心功能的相关性。方法2014年7月-2018年9月华北理工大学附属医院妇产科诊治PCOS孕妇120例为研究对象(病例组),选取同期正常孕妇123例为对照组。比较2组PTX-3、Adropin、HDL-C、LDL-C、SCr、TC、TG、FIB、UA、hs-CRP水平,左心功能(LVEF、LVED、LAD、LVEDD水平);分析PTX-3、Adropin水平与各指标的相关性。结果与对照组比较,病例组PTX-3、TC、TG、LDL-C、FIB、SCr、UA、hs-CRP、LVEDD、LVESD、LAD水平升高(t/P=21.137/0.000、10.709/0.000、9.784/0.000、10.948/0.000、8.084/0.000、16.868/0.000、82.223/0.000、14.742/0.000、12.145/0.000、8.862/0.000、15.669/0.000),Adropin、HDL-C、LVEF水平降低(t/P=12.214/0.000、5.283/0.000、17.782/0.000)。PTX-3与SCr、UA、TC、TG、LDL-C、FIB、hs-CRP、LVEDD、LVESD、LAD呈正相关(r/P=0.465/0.000、0.449/0.000、0.669/0.000、0.556/0.000、0.453/0.000、0.736/0.000、0.586/0.000、0.548/0.000、0.686/0.000、0.489/0.000),与HDL-C、LVEF呈负相关(r/P=-0.449/0.000、-0.563/0.000);Adropin与SCr、UA、TC、TG、LDL-C、FIB、hs-CRP、LVEDD、LVESD、LAD呈负相关(r/P=-0.425/0.000、-0.595/0.000、-0.621/0.000、-0.598/0.000、-0.548/0.000、-0.523/0.000、-0.584/0.000、-0.645/0.000、-0.584/0.000、-0.469/0.000),与HDL-C、LVEF呈正相关(r/P=0.698/0.000、0.593/0.000)。高水平PTX-3、低水平Adropin均为PCOS患者孕期发生严重不良心脏事件的危险因素(OR=2.43、8.36,P<0.05)。结论PCOS患者孕期血清PTX-3水平升高、Adropin水平降低,其与左心功能密切相关;高水平PTX-3及低水平Adropin均为PCOS患者孕期发生严重不良心脏事件的危险因素。
Objective To analyze the changes of serum PTX-3 and adropin levels in patients with polycystic ovary syndrome(PCOS)during pregnancy and their correlation with clinical characteristics and left heart function.Methods From July 2014 to September 2018,120 cases of PCOS pregnant women diagnosed and treated in the Department of Gynecology and Obstetrics of the Affiliated Hospital of North China University of technology were selected as the study object(case group),and 123 cases of normal pregnant women in the same period were selected as the control group.PTX-3,adropin,HDL-C,LDL-C,SCr,TC,TG,FIB,UA,hs-CRP levels and left ventricular function(LVEF,LVED,LAD,LVEDD levels)were compared between the two groups.The correlation between PTX-3,adropin and each index was analyzed.Results Compared with the control group,the levels of PTX-3,TC,TG,LDL-C,FIB,SCr,UA,hs-CRP,LVEDD,LVESD,and LAD increased in the case group(t/P=21.137/0.000,t/P=10.709/0.000,t/P=9.784/0.000,t/P=10.948/0.000,t/P=8.084/0.000,t/P=16.868/0.000,t/P=82.223/0.000,t/P=14.742/0.000,t/P=12.145/0.000,t/P=8.862/0.000,t/P=15.669/0.000),Adropin,HDL-C,and LVEF levels decreased(t/P=12.214/0.000,t/P=5.283/0.000,t/P=17.782/0.000).PTX-3 is positively correlated with SCr,UA,TC,TG,LDL-C,FIB,hs-CRP,LVEDD,LVESD,LAD(r/P=0.465/0.000,r/P=0.449/0.000,r/P=0.669/0.000,r/P=0.556/0.000,r/P=0.453/0.000,r/P=0.736/0.000,r/P=0.586/0.000,r/P=0.548/0.000,r/P=0.686/0.000,r/P=0.489/0.000),negatively correlated with HDL-C and LVEF(r/P=-0.449/0.000,r/P=-0.563/0.000);Adropin and SCr,UA,TC,TG,LDL-C,FIB,hs-CRP,LVEDD,LVESD,LAD are negatively correlated(r/P=-0.425/0.000,r/P=-0.595/0.000,r/P=-0.621/0.000,r/P=-0.598/0.000,r/P=-0.548/0.000,r/P=-0.523/0.000,r/P=-0.584/0.000,r/P=-0.645/0.000,r/P=-0.584/0.000,r/P=-0.469/0.000),which is positively correlated with HDL C and LVEF(r/P=0.698/0.000,r/P=0.593/0.000).High levels of PTX-3 and low levels of Adropin were risk factors for severe adverse cardiac events during pregnancy in PCOS patients(OR=2.43,OR=8.36,P<0.05).Conclusion The high level of PTX-3 and the l
作者
刘萍
温洁
赵楠楠
何艳舫
袁金灵
Liu Ping;Wen Jie;Zhao Nannan;He Yanfang;Yuan Jingling(Department of Obstetrics and Gynecology,Affiliated Hospital of North China University of Technology,Hebei Province,Tangshan 063000,China)
出处
《疑难病杂志》
CAS
2020年第3期271-274,284,共5页
Chinese Journal of Difficult and Complicated Cases
基金
河北省科技厅重点研发项目(18277770D)~~
