摘要
目的:探讨糖类抗原19-9(CA19-9)、甲胎蛋白(AFP)及癌胚抗原(CEA)在原发性肝癌(PLC)诊断中的价值。方法:选取2018年9月-2019年7月笔者所在医院收治的PLC患者50例作为观察组,另选取同时期于医院体检的健康人群50例作为对照组。采用化学发光法检测血清CA19-9、血清CEA水平、血清AFP水平。对比两组上述指标差异,并采用SPSS软件分析血清CA19-9、血清CEA、血清AFP水平单独及联合诊断PLC的效能。结果:观察组血清CA19-9、CEA、AFP水平均高于对照组,差异均有统计学意义(P<0.05)。血清CA19-9、CEA、AFP水平单独诊断PLC的Kappa值由高到低依次为AFP(0.560)、CA19-9(0.540)、CEA(0.400),但均低于三者联合诊断的Kappa值(0.800)。血清CA19-9、CEA、AFP水平单独诊断PLC的Youden指数由高到低依次为AFP(0.560)、CA19-9(0.540)、CEA(0.400),但均低于三者联合诊断的Youden指数(0.800)。结论:血清CA19-9、CEA、AFP水平均对PLC的诊断具有一定的价值,但三者联合诊断效能更高,可作为临床诊断PLC的指标。
Objective:To investigate the value of carbohydrate antigen 19-9(CA19-9),alpha fetoprotein(AFP)and carcinoembryonic antigen(CEA)in the diagnosis of primary liver cancer(PLC).Method:From September 2018 to July 2019,50 patients with PLC in our hospital were selected as the observation group,and 50 healthy people in the same period in our hospital were selected as the control group.Serum CA19-9,serum CEA and serum AFP levels were detected by chemiluminescence method.The differences of the above indexes were compared between the two groups.SPSS software was used to analyze the serum CA19-9,serum CEA,serum AFP levels and the efficacy of combined diagnosis of PLC.Result:The serum levels of CA19-9,CEA and AFP in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The Kappa values of serum CA19-9,CEA and AFP levels from high to low were AFP(0.560),CA19-9(0.540),CEA(0.400),but they were lower than the Kappa value of the combined diagnosis(0.800).The Youden index of serum CA19-9,CEA,and AFP in the diagnosis of PLC from high to low were AFP(0.560),CA19-9(0.540),CEA(0.400),but they were lower than the Youden index of the combined diagnosis(0.800).Conclusion:Serum CA19-9,CEA and AFP levels have certain value for the diagnosis of PLC,but the combination of the three is more effective and can be used as an indicator for clinical diagnosis of PLC.
作者
陈志强
CHEN Zhiqiang(Xinxing County People’s Hospital,Xinxing 527400,China)
出处
《中外医学研究》
2020年第4期50-52,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
原发性肝癌
糖类抗原
甲胎蛋白
癌胚抗原
诊断价值
Primary liver cancer
Carbohydrate antigen
Alpha-fetoprotein
Carcinoembryonic antigen
Diagnostic value
