摘要
目的分析急性敌草快中毒患者死亡的危险因素及其对预后的预测价值。方法收集中国医科大学附属盛京医院急诊科2016年1月至2019年8月收治的41例急性敌草快中毒患者的临床资料,依据随访2个月患者是否死亡,分为死亡组和存活组,比较2组患者一般情况及临床资料,将差异有统计学意义(P<0.05)的指标纳入logistic回归,分析死亡危险因素,并通过ROC曲线评价其预测死亡的效能。结果两组患者服毒剂量、入院时间、丙氨酸氨基转移酶(ALT)和门冬氨酸氨基转移酶(AST)、尿素、血肌酐、氧分压和尿敌草快浓度差异有统计学意义(P<0.05),两组患者的性别、年龄、饮酒率、洗胃率、血液灌流率、白细胞计数、钾离子和乳酸差异无统计学意义(均P>0.05);将上述差异有统计学意义的各变量进一步纳入多元logistic回归方程,通过logistic回归分析后,敌草快剂量、血肌酐、尿敌草快浓度是急性敌草快中毒死亡的独立危险因素(P<0.05)。结论敌草快剂量、血清肌酐和尿敌草快浓度可作为判断急性敌草快中毒病情严重程度及预后的可靠指标。
Objective To analyze the risk factors of death in patients with acute diquat poisoning and provide theoretical basis for further improving the diagnosis and treatment of diquat poisoning. Methods Collection 41 patients in our hospital emergency department from Jan.2016 to Aug.2019 the clinical data of acute diquat poisoning patients, according to whether the patients were followed up for 2 months, and divided into death and survival groups, and compared the patient’s general condition and clinical data, the significant difference(P < 0.05) index into the logistic regression, analysis of death risk factors, and through the ROC curve to evaluate the prediction effectiveness of death. Results Two groups of patients with diquat dose, hospitalized time, ALTand AST, urea, creatinine, oxygen partial pressure and urine concentration of diquat difference was statistically significant(P < 0.05), two groups of patients’ age, gender, alcohol consumption rate, rate of gastric lavage, blood perfusion rate, white blood cell count, potassium and lactic acid differences had no statistical significance(P >0.05);The above variables with statistically significant differences were further incorporated into the multivariate logistic regression. After logistic regression analysis, diquat dose, serum creatinine and urine diquat concentration were independent risk factors for the death of acute diquat poisoning(P < 0.05).Conclusion Diquat dose, serum creatinine and urine diquat concentration can be used to determine the severity and prognosis of acute diquat poisoning.
作者
王鸾
王洋
赵敏
WANG Luan;WANG Yang;ZHAO Min(Emergency Department,Shengjing hospital,China Medical University,Shenyang 110004,China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2020年第2期158-161,共4页
Chinese Journal of Practical Internal Medicine
关键词
敌草快中毒
预后
死亡危险因素
diquat poisoning
prognosis
risk factor of death
