摘要
目的探讨该院近5年金黄色葡萄球菌(SA)的临床分离情况、科室和标本分布特点及其对抗菌药物的耐药性,为临床合理使用抗菌药物和减少耐药菌株提供依据。方法回顾性分析该院2014-2018年住院及门诊患者送检标本分离到的SA数据,采用WHONET 5.6和SPSS 17.0等软件对SA和耐甲氧西林金黄色葡萄球菌(MRSA)的科室分布、标本来源及耐药性等进行统计分析。结果该院5年内共分离到4453株SA,其中MRSA有1637株(占36.76%)。SA和MRSA检出率最多的科室是烧伤科(占19.96%和39.58%),其次是儿科(占17.25%和9.90%);SA和MRSA标本来源以伤口分泌物为主(占32.27%和43.62%),其次是痰液(占31.46%和23.46%)。SA和MRSA对青霉素G的耐药率均在94.1%以上,MRSA对苯唑西林的耐药率在97.1%以上,对替加环素和呋喃妥因的耐药率低,未检出对万古霉素、替考拉宁和利奈唑胺耐药的菌株。结论该院SA和MRSA检出率较高,应定期监测其临床分布和耐药性,强化临床合理使用抗菌药物管理,做好院内感染防控措施。
Objective To study the distribution characteristics of departments and susceptible profile of Staphylococcus aureus(SA)isolated from a teaching hospital in the past 5 years,and to present data for clinical rational use of antibiotics and control of resistant strains.Methods Retrospective method was used to analyze the SA data collected from hospitalized and outpatients from 2014-2018 by using WHONET 5.6 and SPSS 17.0 software for departmental distribution,specimen sources and drug resistance of SA and methicillin-resistant Staphylococcus aureus(MRSA).Results A total of 4453 SAs were isolated in the hospital within 5 years,1637(36.76%)of which were MRSA.The departments with the highest detection quantity of SA and MRSA were burn department(19.96%and 39.58%),followed by pediatrics(17.25%and 9.90%).SA and MRSA isolates were mainly from wound secretions(32.27%and 43.62%),followed by sputum(31.46%and 23.46%).The resistance rates of SA and MRSA to penicillin G were all above 94.1%,while more than 97.1%of MRSA were resistant to oxacillin.The resistance rate to tigecycline and nitrofurantoin was low.None of SA and MRSA strains were resistant to vancomycin,teicoplanin and linezolid.Conclusion The prevalence of SA and MRSA in this hospital is high.The clinical distribution and drug resistance should be monitored regularly,the clinical use of antibiotics should be rationalized,and the prevention and control measures of nosocomial infection should be strictly followed.
作者
杨媚
吴柳
刘智勇
陈鸣
YANG Mei;WU Liu;LIU Zhiyong;CHEN Ming(Department of Laboratory Medicine,the First Affiliated Hospital of Army Medical University,Chongqing 400038,China;Department of Infection Control Management,the First Affiliated Hospital of Army Medical University,Chongqing 400038,China)
出处
《国际检验医学杂志》
CAS
2020年第5期596-599,共4页
International Journal of Laboratory Medicine
基金
陆军军医大学第一附属医院院管课题(SWH2016YSCXYB-15,SWH2016JSTSYB-62)
关键词
金黄色葡萄球菌
耐甲氧西林金黄色葡萄球菌
临床分布
耐药性
Staphylococcus aureus
methicillin-resistant Staphylococcus aureus
clinical distribution
drug resistance
