摘要
目的探讨HSPA1L rs2227956位点单核苷酸多态性与子痫前期遗传易感性的关系。方法采用TaqMan探针实时荧光PCR技术,对山东地区汉族女性中800例子痫前期(PE)病人和1000例正常妊娠孕妇的外周血DNA进行扩增,比较两组HSPA1L rs2227956位点基因型分布和等位基因频率。结果PE组和正常孕妇组HSPA1L rs2227956位点的基因型分布和等位基因频率比较差异无统计学意义(P>0.05)。与正常孕妇组比较,轻度PE组、重度PE组以及早发型PE、晚发型PE组HSPA1L rs2227956位点的基因型分布和等位基因频率差异均无显著性(P>0.05)。结论HSPA1L rs2227956位点多态性与PE的遗传易感性没有相关性。
Objective To investigate the association of HSPA1L rs2227956 single nucleotide polymorphism with genetic susceptibility to preeclampsia(PE).Methods TaqMan real-time PCR was used for the amplification of peripheral blood DNA from 800 patients with PE and 1000 normal pregnant women from the Chinese Han women in Shandong Province,China,and then the two groups were compared in terms of HSPA1L rs2227956 genotype distribution and allele frequency.Results There were no significant differences in HSPA1L rs2227956 genotype distribution and allele frequency between the PE group and the normal pregnant women group(P>0.05).Compared with the normal pregnant women group,no significant differences in HSPA1L rs2227956 genotype distribution and allele frequency were found for the mild PE group and severe PE group,as well as the early-onset PE group and late-onset PE group(P>0.05).Conclusion There is no association between HSPA1L rs2227956 polymorphism and genetic susceptibility to PE.
作者
李胜军
林岩
宗金宝
刘世国
宋卫青
LI Shengjun;LIN Yan;ZONG Jinbao;LIU Shiguo;SONG Weiqing(Clinical Laboratory of Qingdao Women and Children’s Hospital Affiliated to Qingdao University,Qingdao 266034,China)
出处
《青岛大学学报（医学版）》
CAS
2020年第1期26-29,共4页
Journal of Qingdao University(Medical Sciences)
基金
山东省自然科学基金资助项目(ZR2019MH127)
