摘要
转录组测序(RNA-seq)在分析基因融合、剪接变异、基因表达谱等方面有独特的优势,单细胞RNA-seq为揭示正常组织和肿瘤组织中的细胞异质性提供了强大的工具。随着高通量基因测序技术的普及和成本的迅速下降,RNA-seq在血液肿瘤研究中的应用越来越多。现结合第61届美国血液学会年会的报道对相关研究进展进行介绍。
Transcriptome sequencing(RNA-seq)has unique advantages in analyzing gene fusion,splicing mutations,and gene expression profiles.Single-cell RNA-seq provides powerful tools to reveal cellular heterogeneity in normal and tumor tissues.With the widespread application of high-throughput gene sequencing technology and the rapid reduction in cost,RNA-seq is increasingly used in hematological malignancies research.This article introduces the related research progress in conjunction with reports at the 61st American Society of Hematology Annual Meeting.
作者
刘红星
陈雪
王芳
马小丽
袁丽莉
曹泮翔
聂代静
Liu Hongxing;Chen Xue;Wang Fang;Ma Xiaoli;Yuan Lili;Cao Panxiang;Nie Daijing(Beijing Lu Daopei Institute of Hematology,Beijing 100076,China;Department of Clinical Laboratory,Hebei Yanda Lu Daopei Hospital,Langfang 065201,China)
出处
《白血病．淋巴瘤》
CAS
2019年第12期705-708,共4页
Journal of Leukemia & Lymphoma
关键词
高通量核苷酸测序
转录组
基因测序
融合基因
基因突变
血液肿瘤
High-throughput nucleotide sequencing
Transcriptome
Gene sequencing
Fusion genes
Gene mutations
Hematological malignancies
