摘要
目的了解前列腺癌患者的观察生存率及其相关资料,为临床评估患者疗效和预后提供参考依据。方法回顾性分析2011年1月1日-2018年12月31日医院肿瘤随访登记中心系统的前列腺癌患者信息,采用SPSS22.0统计软件进行统计分析,各年度患者的基本信息采用χ^2检验进行统计分析;生存数据采用Kaplan-Meier法绘制生存曲线,采用对数秩检验进行生存曲线比较,比较不同年龄段、临床分期前列腺癌患者的生存率差异。结果629例前列腺癌患者平均年龄为72.66±9.17岁,最小年龄27岁,最大年龄98岁,不同时间段的患者年龄分布差异无统计学意义(χ^2=6.381,P=0.382);有临床分期的患者598例,占95.07%,不同时间段收治的前列腺癌患者临床分期分布差异有统计学意义(χ^2=22.278,P=0.008);随访结果中死亡患者114例,占18.12%,失访51例,占8.11%,存活464例;前列腺癌患者的平均生存时间为65.02月,1年-5年观察生存率分别为81.18%、74.06%、67.11%、64.58%、62.00%,不同年龄段间生存率差异无统计学意义(χ^2=2.136,P=0.344);不同临床分期间差异有统计学意义(χ^2=12.283,P=0.006)。结论前列腺癌患者的年龄不是影响患者生存预后的危险因素,临床分期会对前列腺癌患者的生存预后造成一定的影响,其中分期越早的患者预后效果越好。
Objective To understand the observed survival rate of patients and relevant data,and provide reference basis for clinical evaluation of patients’efficacy and prognosis.Methods The retrospective analysis was performed on 629 prostate cancer patients discharged from the hospital on January 1 st,2011 to December 31 st,2018 according to the hospital tumor follow-up registration center system.SPSS22.0 statistical software was used for statistical analysis,andχ~2 test was used for statistical analysis of patients’basic information in each year.Kaplan-Meier method was used to draw survival curves and the survival rates of cancer patients of different ages and clinical stages were compared by log-rank test.Results The mean age of 629 patients with prostate cancer was 72.66±9.17 years old,with the minimum age of 27 years old and the maximum age of 98 years old.There was no significant difference in the age distribution of patients in different time periods(χ~2=6.381,P=0.382).There were 598 patients with clinical stages,accounting for 95.07%.In different time periods,there were statistically significant differences in clinical stages among patients with prostate cancer(χ~2=22.278,P=0.008).Among the follow-up results,114 patients died,accounting for 18.12%,51 patients lost follow-up,accounting for 8.11%,and 464 patients survived.The mean survival time of patients with prostate cancer was 65.02 months,and the observed survival rates at 1,2,3,4 and 5 years were 81.18%,74.06%,67.11%,64.58%and 62.00%,respectively.There was no statistically significant difference in survival rates among different age groups(χ~2=2.136,P=0.344).However,there were statistically significant differences between different clinical stages(χ~2=12.283,P=0.006).Conclusions Age was not a risk factor affecting the survival and prognosis of patients with prostate cancer,but clinical stage will have a certain impact on the survival and prognosis of patients,among which the earlier the stage,the better the prognosis.
作者
李小升
赵玉兰
陈习田
陈威龙
张烜
沈开凤
龚玲芳
李小琼
周紫微
何美
杨开浩
雷海科
周宏
Li Xiaosheng;Zhao Yulan;Chen Xitian;Chen Weilong;Zhang Xuan;Shen Kaifeng;Gong Lingfang;Li Xiaoqiong;Zhou Ziwei;He Mei;Yang Kaihao;Lei Haike;Zhou Hong(Chongqing University Cancer Hospital&Chongqing Cancer Institute&Chongqing Cancer Hospital,Chongqing 400030,China)
出处
《中国病案》
2019年第11期109-112,共4页
Chinese Medical Record
基金
重庆市技术创新与应用发展专项(cstc2019jscx-fxyd0025)
重庆市技术创新与应用示范项目(cstc2018jscx-msyb X0075)
沙坪坝区决策咨询与管理创新指导性计划项目(Jcd201947)
重庆市医学科研计划项目(2013-2-123)
关键词
前列腺癌
登记
随访
生存率
Prostatic cancer
Registration
Follow-up
Survival rates
