摘要
建立一种运用拉曼光谱技术直接快速定量阿哌沙班固体制剂中微晶纤维素的方法。通过在高信噪比的拉曼光谱数据中引入高阶导数概念,有效提升了光谱选择性,消除基线的低频影响,克服了传统拉曼光谱定量分析中遇到的问题。采用微晶纤维素含量不同的阿哌沙班固体制剂建立标定曲线,该工作曲线线性相关系数r值为0.9986。该方法测试结果显示相对误差在5%以内,精密度小于3%。结果可满足固体制剂中组分含量分析的要求。
A method for the direct and rapid quantification of microcrystalline cellulose in a solid form of apixaban using Raman spectroscopy was established. By introducing a high-order derivative concept in Raman spectral data with high SNR, the spectral selectivity is effectively improved, the low-frequency effects of the baseline are eliminated, and the problems in the conventional Raman spectroscopy quantitative analysis are overcome. The calibration curve was established by using apixaban solid preparation with different microcrystalline cellulose concentration. The linear correlation coefficient r value of the working curve was 0.9986. The test results of the method show that the relative error is within 5% and the precision can be less than 3%. The results can meet the requirements of component content analysis in solid preparations.
作者
韩莹
徐记各
忻欣
方凤
姚志湘
侯翊敏
白芳
HAN Ying;XU Jige;XIN Xin;FANG Feng;YAO Zhixiang;HOU Yimin;BAI Fang(CSEPAT(Beijing)Technology Co.,Ltd.,Beijing 100029,China;Zhejiang Better Pharmaceuticals CO.,Ltd.,Shaoxing 312071,Zhejiang,China;Guangxi Key Laboratory of Green Processing of Sugar Resources,Guangxi University of Science and Technology,Liuzhou 545006,Guangxi,China;University of Science and Technology Beijng,Beijing 10083,China;Key Laboratory of Green Process and Engineering,Institule of Process Engineering,CAS,Beijing 100190,China;School of Chemical and Engineering,University of Chinese Academy of Sciences,Beijing 101408,China;Zhongke Langfang Institute of Process Engineering,Langfang 065001,Hebei,China)
出处
《计算机与应用化学》
CAS
北大核心
2019年第4期350-352,共3页
Computers and Applied Chemistry
关键词
拉曼光谱
固体制剂
高阶导数
定量分析
Raman spectroscopy
Solid Preparation
High-order derivative
Quantitative Analysis
