摘要
转化生长因子-β(TGF-β)是TGF-β超家族中的一种多肽类细胞因子,TGF-β信号通路可调控细胞生物学活性,在肿瘤发生发展过程中发挥双向调节作用.该信号传导通路可通过诱导细胞过度增殖、影响肿瘤微环境、调节免疫逃避等引起卵巢癌发生、发展.以TGF-β为生物标志物的卵巢癌靶向治疗为改善患者预后提供了新的路径.
The transforming growth factor-β(TGF-β)is a polypeptide cytokine,belonging to the TGF-βsuperfamily.TGF-βsignaling pathway can regulate cell biological activity and play a bidirectional regulatory role in the development and progression of cancer.TGF-βsignaling pathway can cause the occurrence and development of ovarian cancer through various processes including inducing cell excessive proliferation,influencing tumor microenvironment and regulating immune evasion.Targeted therapy with TGF-βas a biomar-ker for ovarian cancer provides a new way to improve the prognosis of patients.
作者
唐南敏
于占彩
Tang Nanmin;Yu Zhancai(Department of Gynaecology and Obstetrics,People′s Hospital of Longchang City,Sichuan Province,Longchang 642150,China;Department of Oncology,Weihai Municipal Hospital,Shandong Province,Weihai 264200,China)
出处
《国际肿瘤学杂志》
CAS
2019年第9期562-565,共4页
Journal of International Oncology
关键词
卵巢肿瘤
转化生长因子-Β
分子靶向治疗
Ovarian neoplasms
Transforming growth factorβ
Molecular targeted therapy
