摘要
目的检测妊娠晚期GBS感染患者血清C-反应蛋白(CRP)、降钙素原(PCT)、白介素-6(IL-6)表达水平,并探讨CRP、PCT、IL-6检测在妊娠晚期B族链球菌(GBS)感染患者妊娠结局预测中的价值。方法选取2017年3月至2018年6月在佛山市禅城区中心医院行产前检查、住院分娩的孕妇为研究对象,其中50例GBS筛查阳性发生胎膜早破者归入胎膜早破组,50例GBS筛查阳性早产临产者归入早产临产组,50例GBS筛查阳性足月临产者归入GBS对照组,再随机选择50例GBS筛查阴性者归入空白组。采用PCR法确定孕妇及新生儿GBS感染情况,采用ELISA法检测血清CRP、PCT、IL-6水平,比较CRP、PCT、IL-6对不良妊娠结局的预测价值。结果胎膜早破组、早产临产组妊娠晚期GBS感染患者分娩前、分娩后1d、分娩后3d血清CRP、PCT、IL-6表达水平均显著高于GBS对照组、空白组(P<0.05),GBS对照组患者分娩前、分娩后1d、分娩后3d血清CRP、PCT、IL-6表达水平均显著高于空白组(P<0.05),4组孕妇分娩后1d血清CRP、PCT、IL-6表达水平均显著高于分娩前(P<0.05);胎膜早破组、早产临产组及GBS对照组新生儿GBS感染率显著高于空白组(P<0.05);分娩前血清CRP、PCT、IL-6水平及三者联合诊断妊娠晚期GBS感染患者不良妊娠结局的曲线下面积分别为0.752、0.793、0.873,三者联合检测妊娠晚期GBS感染患者不良妊娠结局的曲线下面积为0.930。结论 CRP、PCT、IL-6在妊娠晚期GBS感染患者妊娠结局预测中具有较高的价值,可能作为临床监测及预防不良妊娠结局的重要指标。
Objective To detect the levels of serum C-reactive protein(CRP), procalcitonin(PCT), and interleukin-6(IL-6) in patients with group B streptococcus(GBS) infection in the third trimester of pregnancy, and to explore the values of CRP, PCT, and IL-6 detections in predicting pregnancy outcomes of such patients. Methods From March 2017 to June 2018, pregnant women who underwent prenatal examination and in-patient delivery in the Foshan Chancheng Central Hospital were selected as the study subjects. Among them, 50 cases of premature rupture of membranes with positive GBS screening results were classified as premature rupture of membranes group, 50 cases of premature parturient with positive GBS screening results were classified as premature parturient group, and 50 cases of full-term parturient with positive GBS screening results were classified as GBS control group. Another 50 GBS negative pregnant women were randomly selected and classified as the blank group. The infection of GBS in pregnant women and newborns was determined by PCR, and levels of serum CRP, PCT, and IL-6 were detected by ELISA. The predictive values of CRP, PCT, and IL-6 on adverse pregnancy outcomes were compared. Results The serum expression levels of CRP, PCT, and IL-6 in premature rupture of membranes group and premature parturient group were significantly higher than those of GBS control group and blank group before delivery, 1 day after delivery, and 3 days after delivery(P<0.05). The levels of CRP, PCT, and IL-6 in GBS control group were significantly higher than those in blank group before delivery, 1 day after delivery, and 3 days after delivery(P<0.05). The serum levels of CRP, PCT, and IL-6 in the four groups at 1 day after delivery were significantly higher than those before delivery(P<0.05). The GBS infection rate in premature rupture of membranes group, premature parturient group, and GBS control group was significantly higher than that in blank group(P<0.05). The areas under the curve of serum CRP, PCT, and IL-6 levels before deliver
作者
杨仪心
叶小凤
劳力
张映辉
苏敏
劳武斌
YANG Yixin;YE Xiaofeng;LAO Li;ZHANG Yinghui;SU Min;LAO Wubin(Department of Obstetrics,Chancheng Central Hospital,Foshan 528000,Guangdong,China)
出处
《中国性科学》
2020年第1期91-94,共4页
Chinese Journal of Human Sexuality
基金
佛山市卫生和计划生育局医学科研课题立项(201701768)
关键词
B族链球菌
C-反应蛋白
降钙素原
白介素-6
妊娠结局
Group B streptococcus(GBS)
C-reactive protein
Procalcitonin
Interleukin-6
Pregnancy outcome
