摘要
目的:观察优化饮食干预对维持性血液透析(MHD)患者继发性甲状旁腺功能亢进(SHPT)患者整体健康的影响。方法:70例行MHD治疗且合并SHPT的患者根据入院先后顺序分为2组,每组35例;对照组予以阿法骨化醇软胶囊、碳酸钙片等药物治疗及常规饮食宣教,干预组在对照组治疗基础上实施优化饮食干预方案,干预时间为3个月。检测2组患者干预前后血清钙、磷、全段甲状旁腺激素(iPTH)水平,计算钙磷乘积。同时使用SF-36量表对患者健康状况进行评估。结果:2组患者干预前血清钙、磷、iPTH水平及钙磷乘积差异无统计学意义;干预后干预组较对照组血钙水平升高,而血磷、iPTH水平及钙磷乘积降低,差异均有统计学意义(P<0.05);SF-36的综合测量项目评分、各因子及总均分均明显高于对照组(P<0.01)。结论:优化饮食干预可明显改善MHD合并SHPT患者血清钙磷水平,并且使SF-36量表各维度分值得到有效改善。
Objective:To observe the effect of optimized dietary intervention on secondary hyperparathyroidism(SHPT)in patients with maintenance hemodialysis(MHD).Methods:Seventy patients undergoing MHD and SHPT were divided into two groups according to their admission time,with 35 cases in each group.The control group was treated with Alfacalcicol soft capsules,calcium carbonate tablets and other dietary treatments,while an optimized diet intervention was implemented in the intervention group,based on the routine treatment.The experiment lasted for three months.Serum calcium,phosphorus,and whole-parathyroid hormone(iPTH)levels were measured before and after intervention in both groups,and the calcium-phosphorus product was calculated.Meanwhile,every result was given a certain score respectively by using the SF-36 scale.The score refers to the score of all items added in the comprehensive questionnaire.Results:The blood calcium levels were increased after intervention in both groups(P<0.05).The levels of phosphorus,iPTH and calcium and phosphorus were lower(P<0.05),and the decline degree of serum phosphorus,iPTH and calcium and phosphorus product were higher in the intervention group than in the control group(P<0.05).The scores,factors and total scores of the two comprehensive measurement items of SF-36 in intervention group were significantly higher than those in the control group(P<0.01).Conclusion:Optimized dietary intervention can significantly improve serum calcium and phosphorus levels in patients with MHD and SHPT,and effectively improve the scores of SF-36.
作者
王燕
王德光
王菊霞
WANG Yan;WANG Deguang;WANG Juxia(Department of Nephrology,Fuyang Affiliated Hospital of Anhui Medical University,Fuyang 236000,China;Department of Nephrology,the Second Affiliated Hospital of Anhui Medical University,Hefei 230000,China.)
出处
《温州医科大学学报》
CAS
2020年第2期162-165,共4页
Journal of Wenzhou Medical University
