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多囊卵巢综合征患者血清基质金属蛋白-9表达研究 被引量:1

Research on the changes of serum BMP-9 expression in patients with polycystic ovary syndrome
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摘要 多囊卵巢综合征(polycystic ovary syndrome,PCOS)是青年生育女性比较常见的内分泌代谢疾病。PCOS的发病机制尚未统一,目前比较普遍支持的是与胰岛素抵抗、遗传、慢性炎症等多因素有关。基质金属蛋白-9(BMP-9)是骨形态发生蛋白家族中的一种,是当前BMPs已知的成骨能力最强的因子。相关研究表明.BMP-9可能来源于血清和颗粒细胞。研究发现BMP-9在调节糖、脂代谢方面具有重要功能⑴。关于BMP-9与PCOS的关系目前研究较少。BMP-9在PCOS患者中的变化如何?是否与血脂、胰岛素抵抗等有关。本研究以PCOS人群为对象,对血清BMP-9水平与胰岛素抵抗和脂代谢指标之间的相关性进行探讨。
作者 于晓蕾 陈新卫 张贺 任路平 YU Xiao-lei;CHEN Xin-wei;ZHANG He;REN Lu-ping(Graduate School of Hebei Medical University,Zhangjiakou 075000,China)
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2020年第1期58-61,共4页 Chinese Journal of Practical Internal Medicine
基金 河北省自然科学基金(H2015307034)
关键词 多囊卵巢综合征 胰岛素抵抗 脂代谢 骨形态发生蛋白9 polycystic ovary syndrome insulin resistance fat metabolism bone morphogenetic protein 9
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